Can purpura nephritis in children be cured?

Can purpura nephritis in children be cured?

Childhood purpura nephritis, also known as Henoch-Schonlein purpura nephritis, is an immune disease that causes kidney damage due to systemic small vessel inflammation. After all, childhood purpura nephritis is a kidney disease. When it occurs in children, it has a great impact on their health. In addition to being most concerned about treatment, parents are most concerned about whether it can be cured. So, can purpura nephritis in children be cured? Let’s take a look below.

According to different classification standards, there are three classification methods for childhood purpuric nephritis: ① Clinical classification of childhood purpuric nephritis, which is mainly based on the common clinical symptoms of children with purpuric nephritis; ② Pathological classification of childhood purpuric nephritis, which is mainly based on pathological changes after light microscopy of renal biopsy; ③ Immunopathological classification of childhood purpuric nephritis, which is mainly based on the deposition of immune complexes after fluorescent examination of renal biopsy, and is divided into IgA; IgA+IgG; IgA+IgM; IgA+IgG+IgM.

treat

There is currently no specific treatment for purpuric nephritis in children. Symptomatic treatment is the main treatment, with attention paid to protecting renal function.

1. Lightweight

No special treatment is required, and symptomatic and supportive treatment is the main approach, avoiding contact with allergy-causing foods and drugs. Sensitive antibiotics can be used when there is clear infection.

2. Acute nephritic syndrome

The main functions are to lower blood pressure, promote diuresis, control infection foci, and protect kidney function. Specific medication is the same as that for acute glomerulonephritis.

3. Nephrotic syndrome

Adrenal cortical hormones can be used, usually prednisone.

4. Rapidly progressive nephritis and chronic nephritis

The treatment is usually combined with hormones, cytotoxic drugs, anticoagulants and traditional Chinese medicine. Renal failure can be treated with dialysis. For rapidly progressive nephritis, methylprednisolone pulse therapy can be used early.

Prognosis

More than half of children with Henoch-Schonlein purpura can recover from kidney damage on their own, but a small number of children still have persistent hematuria, proteinuria and hypertension for a long time. About 2% of children develop end-stage nephritis, especially those with glomerulonephritis showing crescent formation in pathological examination. More than 80% of them develop end-stage nephritis within 1 year.

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