Treatment options for precocious puberty in girls

Due to the current comprehensive dietary structure and the avant-garde cultural communication, many girls now suffer from precocious puberty. Precocious puberty affects the health of children, so many parents must pay attention to it. The following content specifically introduces the treatment plan for precocious puberty in girls, so you can have a comprehensive understanding of it.

The treatment of this disease depends on the cause. The treatment goals of central precocious puberty are: 1. inhibit or slow down development, especially to prevent girls from menstruating, 2. inhibit skeletal maturation and improve the final rise in adulthood, and 3. restore the psychological behavior that should be expected at the corresponding age.

1. Etiological treatment

Those caused by tumors should be surgically removed or undergo chemotherapy. Those caused by radiotherapy or hypothyroidism should be given thyroid preparations to correct thyroid function. Patients with congenital adrenal hyperplasia can be treated with cortisol hormones.

2. Drug treatment

1. Gonadotropin-releasing hormone analogue (GnRHa)

Natural GnRH is a 10-amino acid polypeptide. The several commonly used GnRHs are long-acting synthetic hormones made by replacing the sixth amino acid in the molecule, namely glycine, with D-tryptophan, D-serine, D-histidine, and D-leucine. Their function is to reduce the secretion of pituitary gonadotropin by down-regulation, thereby restoring estrogen to pre-pubertal levels. It can be injected intramuscularly once every 4 weeks at a dose of 0.1 mg/kg. After taking the medicine, the patient's sexual development, height growth, and bone age maturation can be controlled. Its effect is reversible. If treated as early as possible, it can improve the final height in adulthood.

2. Sex hormones

Its mechanism of action is to use high-dose sex hormone feedback to inhibit hypothalamic-pituitary gonadotropin secretion. For example, medroxyprogesterone acetate, also known as medroxyprogesterone acetate, is a progesterone derivative used for precocious puberty in girls. The daily oral dose is 10 to 30 mg, and the dose is reduced to maintain efficacy after the effect is shown. Cyproterone acetate is a 17-hydroxyprogesterone derivative that not only blocks sex hormone receptors but also reduces the release of gonadotropin. The daily dose is 70-150 mg/m2. The above two drugs cannot improve adult height.

Tip: In terms of drug treatment, mild precocious puberty can be treated with Chinese medicine such as Zhibai Dihuang Pills, Dayin Bu Pills and other decoctions; moderate or above and true precocious puberty can be treated with progesterone and gonadotropin-releasing hormone drugs under the guidance of a doctor.

Treatment plan for precocious puberty in girls. Through the comprehensive understanding above, I believe that many parents have fully understood the treatment plan for precocious puberty in girls. Therefore, after fully understanding, when their children show precocious puberty, they should use the treatment plan introduced above to give their children effective treatment and keep their children away from precocious puberty.