Neonatal Sepsis

Sepsis is a disease caused by bacterial invasion. Newborns have weaker resistance and are more easily invaded by bacteria, making them more susceptible to neonatal sepsis. After contracting this disease, the child will have gastrointestinal problems, affecting the newborn's absorption of nutrients and being detrimental to growth. In severe cases, it can affect the functions of organs such as the spleen, so parents should cooperate with the doctor for treatment in a timely manner when they find that their newborn is ill. So what exactly is neonatal sepsis?

Sepsis refers to the invasion of purulent bacteria into the bloodstream, their massive multiplication therein, and their spread through the bloodstream to other tissues or organs of the host body, producing new purulent lesions. There are more serious primary infection lesions, systemic inflammatory reactions such as high fever 40-41℃ or T<36.5℃, gastrointestinal reactions, dyspnea, weak and rapid pulse; septic shock, hepatosplenomegaly, jaundice

;Metabolic disorders;Renal damage: proteinuria, tubular urine; elevated white blood cell count, greater than 20,000-30,000, with left shift of nuclei and appearance of toxic particles; positive blood bacterial culture. In addition, organ abscesses may occur in the lungs, liver, brain, and kidneys, especially lung abscesses, which are the most common. Mediastinal infections and subphrenic abscesses may also occur.

For the treatment of sepsis, re-induction therapy may be considered. If the immunosuppressive factors cannot be eliminated during the maintenance period (such as continued use of immunosuppressants), the maintenance treatment course should be extended or the immunosuppressive period should be treated 3 to 5 times a week to avoid recurrence of the disease.

During medication, routine blood tests and liver and kidney function should be monitored. If jaundice significantly worsens and liver function deteriorates, platelets drop to ≤25×109/L, granulocytes drop to 0.5×109/L, or decrease to 50% of the pre-medication level, the medication should be discontinued. Neutropenia is reversible and can generally be recovered within 5 to 7 days after drug discontinuation. In severe cases, granulocyte colony-stimulating factor can be given. If treatment is required again, the original dose or a reduced dose can be used, or colony-stimulating factor can be used in combination to reduce bone marrow toxicity.