Nephrotic syndrome mortality in children

Many children suffer from pediatric kidney diseases right after they are born. This disease is very harmful to children and the possibility of being cured is relatively low. In the process of cure, a lot of money will be spent and the children will suffer great pain. Therefore, many mothers will choose to give up treatment. So is the probability of death from pediatric nephrotic syndrome high?

Mortality rate of nephrotic syndrome in children

Of course, the probability of nephrotic syndrome leading to death is not high. For most patients, the condition can be controlled after effective treatment, and nephrotic syndrome can be clinically cured. Children with nephrotic syndrome can be clinically cured if they are treated actively in the early stages, so there is no such thing as a five-year or ten-year survival rate like cancer.

The main manifestations are hypertension, hyperlipidemia, massive proteinuria and hypoproteinemia. Generally, hormone treatment is the main treatment. In traditional Chinese medicine, it is related to yang deficiency and water deficiency, and can be treated with Zhenwu Decoction. It can also cause some corresponding consequences or complications. Not every patient will experience these complications, and these complications can lead to the patient's death.

Nephrotic syndrome is clinically curable. Children's nephrotic syndrome can be clinically cured if treated actively at an early stage, so there is no such thing as a 5-year or 10-year survival rate like cancer.

Hormone therapy is the first choice for primary nephrotic syndrome in children. Things to note: The initial dose must be sufficient. Most children with nephrotic syndrome are under 18 years old. The dose is determined based on body surface area or kilograms of body weight, generally 1-2 mg of prednisone or prednisolone per kilogram of body weight. People with liver disease use prednisolone because prednisone needs to be converted into prednisolone by the liver. Prednisone is 2 cents per tablet, while methylprednisolone is 1-2 yuan per tablet. The more expensive it is, the better it is not. Methylprednisolone has a strong and long-lasting effect, inhibiting the hypothalamic, pituitary, and adrenal cortex axis, resulting in difficulty in reducing dosage, dependence, and infection.

The dosage should be reduced slowly. After sufficient hormone treatment takes effect, the dosage should be reduced slowly instead of stopping suddenly, otherwise there will be a rapid rebound and side effects such as moon face, buffalo hump, centripetal obesity, acne, infection, decreased bone density, etc. Medication recommendations are summarized from experience and should be taken as directed by the doctor. The maintenance time is long, with medication for at least 7 months, and recurrence lasting up to 1-2 years. The situations in which drug treatment other than hormones is required include: resistance to hormones, ineffectiveness of adequate hormones after more than 12 weeks, and consideration of adding immune preparations for treatment. If the side effects of hormones are unacceptable, hormone-free treatment can be used. CTX (cyclophosphamide), cyclosporine, FK506 (Prograf, tacrolimus), azathioprine (Imuran), MMF (mycophenolate mofetil), etc. are used to treat nephrotic syndrome under the guidance of a doctor. But the side effects are greater than hormones. Although there is no abnormality in body fat distribution, changes in appearance, bone necrosis, etc., there may be unpredictable infections, a decrease in white blood cells, damage to the gonads, liver damage, kidney damage, high blood sugar, etc.