What is the cause of testicular dysplasia in boys?

Stunting development in boys is an extremely serious disease, which will lead to developmental disorders in many aspects, such as the brain and body organs. Stunting development in any part of the body will affect the patient's growth and even future life and work. Patients with developmental disabilities must be discovered and diagnosed early so that accurate treatment can be given. At this time, we also need to clarify the disease factors, so what is the cause of testicular dysplasia in boys?

1. Testicular dysplasia, also known as Klinefetter syndrome, is a sex chromosome disease with a high incidence. It was first reported in 1942 before chromosome identification. In 1956, Bradbury et al. showed that the patient's somatic cells showed female X chromatin. In 1959, the chromosome karyotype of the patient was found to be 47, XXY. Abnormal sex chromosomes can lead to testicular dysplasia, infertility, mental retardation, etc.

2. This disease is caused by abnormal sex chromosomes. Most patients have an extra X chromosome. Therefore, the most common peripheral blood leukocyte chromosome karyotype is 47,XXY, or mosaic 47,XXY/46,XX or 47,XXY/48,XXXY, or even more X chromosomes, such as 49,XXXXY. Oral mucosal X body examination positive in XXY karyotype accounted for 93%.

3. Trisomy XXY: Males have two X chromosomes. They may have lower testosterone levels and breast development closer to that of women. Rare cases include XXXY or XXXXY.

The main causes of testicular dysplasia are:

1. Microtestis is mostly caused by congenital testicular hypoplasia, with an incidence rate of 1 in 1000-1500, which means that every medium-sized primary and secondary school will have at least one or two students with microtestis. It is mainly caused by sex chromosome abnormalities. A normal male has 46 chromosomes, represented by 46XY. Patients with microtestis have an extra sex chromosome, x. Congenital small testicles require a chromosome test at a specialist hospital for diagnosis. It is understood that in patients with congenital testicular hypoplasia, the testicular volume is generally less than 6 ml in adulthood, and the intellectual development is slightly poor. Among congenital testicular dysplasia, there is a type called pituitary testicular dysplasia, in which the testicles are small, soft in texture, and the intelligence is slightly better.

2. Some patients with microtestis have acquired factors, such as testicular damage caused by trauma, accidents or surgery. I had mumps and orchitis during adolescence. Suffering from varicocele. Long-term x-ray irradiation of the testicles. Underwear that is too tight or taking hot baths too frequently. People with endocrine diseases take drugs that damage the testicles. Long-term heavy smoking and drinking. Testicular nerve dysplasia caused by trauma will result in the testicles in adulthood being only the size of a peanut or a broad bean, with a very hard texture and a volume of only about 3-6 ml.

3. The causes of azoospermia are complicated, including blockage of the vas deferens, epididymitis, blockage or absence of the vas deferens and ejaculatory duct caused by inflammation, injury, deformity, etc.: testicular spermatogenesis failure also includes congenital testicular dysplasia, trauma, inflammation, vascular disease, and interference with scrotal temperature regulation; systemic factors include congenital testicular dysplasia, including endocrine diseases, genetics, nutritional disorders, and radiation exposure.

There are many reasons for testicular dysplasia in boys. The most important one is congenital. When the sperm and egg combine, chromosomal abnormalities occur, which will directly lead to the development of the fetus in the future. Of course, some patients are caused by acquired factors. Boys must have physical examinations in all aspects during their growth. It is best to have a pediatric examination once a year to confirm the health of the body and receive immediate treatment if there is any disease.