What causes high platelet count in children?

What is the reason for thrombocytopenia in children at birth? Premature destruction or excessive consumption of platelets can easily lead to thrombocytopenia. The lifespan of platelets is relatively short, and the number of megakaryocytes in the bone marrow is relatively normal or there is compensatory hyperplasia. Because of this situation, the symptoms of thrombocytopenia are very complicated. So what is the reason for platelet problems in children?

Immune destruction: drug-related antibodies, production of corresponding antibodies. Certain diseases with abnormal immune responses can cause immune platelet destruction. Infection-related thrombocytopenia is common in viral and bacterial infections. Alloimmune thrombocytopenia, seen in post-transfusion purpura and neonatal purpura, is the cause of thrombocytopenia.

Non-immune destruction: The vascular endothelium is rough, and foreign bodies in the blood vessels cause mechanical destruction of platelets. Causes of thrombocytopenia include vasculitis, artificial heart valves, arterial catheterization, extracorporeal circulation, hemodialysis, etc. Disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome are all accompanied by thrombocytopenia, which is related to excessive platelet consumption.

Causes of thrombocytopenia in children:

Children are generally normal at birth. However, only a few hours or 24 hours after birth, extensive bleeding spots and ecchymosis will appear. Vomiting blood, nose bleeding, blood in the stool, umbilical oozing, etc. may also occur. In severe cases, intracranial hemorrhage may occur, and blood tests may show a decrease in platelet count.

Thrombocytopenic purpura If the pregnant mother has thrombocytopenia or takes medication, the newborn will have thrombocytopenia and cause bleeding. Immune, infection and other factors can also cause thrombocytopenia and the disease. Improper use of medication by pregnant mothers and infection are all causes of thrombocytopenia in children. For patients who become ill due to improper use of medication, their condition will generally improve after a week; patients who become ill due to infection need to receive effective treatment after the infection is controlled; and severe patients require blood exchange or transfusion treatment.

The occurrence of thrombocytopenia in children will not only have an adverse effect on the health and growth of pediatric patients, but also increase the psychological burden of parents. Therefore, we need to take timely preventive and therapeutic measures based on the cause of thrombocytopenia in children.

Another type is caused by the pregnant mother's medication. He said that the condition will gradually improve and recover very well after a week. If it is caused by other reasons, corticosteroids can be used for treatment, and fresh blood can be transfused according to the symptoms.