Children with Henoch-Schonlein Purpura

Allergic purpura is a very common skin disease. Allergic purpura usually causes the patient's skin to develop many spots due to light touch or after infection with allergens. There may even be urticaria-like rashes that may disappear in a short time and become more and more serious. Severe patients may also have kidney failure and need early treatment.

Baby allergic purpura

Basic Overview of Henoch-Schonlein Purpura

There is often a history of upper respiratory tract infection 1 to 3 weeks before onset. It manifests as skin petechiae, which mostly appear around the joints of the lower limbs and buttocks. Purpura is symmetrically distributed, appears in batches, varies in size, and varies in color. It can merge into pieces and generally disappears gradually within a few days, but can recur. Patients may have gastrointestinal symptoms, such as paroxysmal abdominal colic or persistent dull pain; they may have joint pain; kidney symptoms, such as proteinuria and hematuria, are more common in children. Treatment includes trying to find the cause of the allergy and avoiding it; using antihistamines such as diphenhydramine, promethazine, anhydride, chlorpheniramine, etc. and corticosteroids, etc.

Clinical manifestations of Henoch-Schonlein purpuraGo Top

It is common in children aged 3 to 10 years old, and begins with purpura of the skin and mucous membranes, accompanied by fever, headache, malaise and loss of appetite. Occasionally, abdominal colic or joint pain is the main symptom. The earliest cutaneous manifestation is an urticarial rash of small, scattered petechial spots that generally become hemorrhagic within a day. It often occurs on the extensor side of the limbs and buttocks and is symmetrical. Renal damage occurs in approximately 50% of cases, ranging from mild nephritis to severe renal failure.

Principles of treatment of Henoch-Schonlein purpuraGo Top

1. Try to eliminate the allergenic factors.

2. For simple cases, compound rutin, calcium supplements, vitamin C, and antihistamine preparations can be used.

3. Corticosteroids can be used for fever and arthritis, but they cannot prevent kidney invasion. Immunosuppressants can be added for patients with stubborn chronic nephritis.

4. Traditional Chinese Medicine: Treat based on syndrome differentiation and clinical symptoms of the disease.

Drugs for the treatment of Henoch-Schonlein purpuraGo Top

1. Anti-allergic drugs: Astemizole, Chlorpheniramine, and calcium gluconate.

2. Drugs that reduce vascular permeability: Anluoxue, rutin, and vitamin C.

3. Platelet aggregation inhibitor: Dipansentin.

4. Adrenal cortical hormones: hydrocortisone, prednisone (prednisone), and dexamethasone.

5. For patients with renal type or those who do not respond well to prednisone, immunosuppressants (such as cyclophosphamide, azathioprine and other chemotherapy drugs) are also used.