How to treat precocious puberty in girls

With the progress of the times, people's living standards have also changed greatly. Many people tend to be precocious, especially the problem of precocious puberty in girls is more prominent. For those precocious girls, are there any treatment methods? If so, how should it be treated? Below I will give you a detailed introduction to the relevant details, hoping it will be helpful to everyone.

Precocious puberty refers to the early onset of puberty, that is, the appearance of gonadal enlargement and secondary sexual characteristics in females before the age of 8, or the appearance of menstruation before the age of 10, and the development of males before the age of 9. According to the different pathogenesis, precocious puberty can generally be divided into two categories: gonadotropin-releasing hormone (GnRH)-dependent precocious puberty (true precocious puberty) and non-GnRH-dependent precocious puberty (pseudo-precocious puberty); the former is called central precocious puberty or complete precocious puberty, and the latter is called peripheral precocious puberty. In addition, incomplete precocious puberty, such as simple premature breast development and simple premature pubic hair, are classified as variant types of puberty by some scholars.

1. Girls' precocious puberty requires a detailed diagnosis: First, all obvious causes of precocious puberty must be ruled out, such as accidental ingestion of endocrine drugs. This requires a detailed and complete medical history, including sexual characteristics development, vaginal bleeding, etc. A careful and comprehensive physical examination is performed, such as body, weight, finger spacing, bone examination, basal body temperature, vaginal cell smear, etc. The determination of blood hormone levels helps to distinguish true from false precocious puberty. In true precocious puberty, the FSH and LH levels are increased and fluctuate periodically, while in false precocious puberty, these two hormones are often undetectable.

2. Treatment should be based on the specific cause: if there is an ovarian or adrenal cortex tumor, surgical treatment is necessary, while there is no special treatment for those caused by nervous system diseases. 80-90% of precocious puberty is a physical problem with no obvious cause and no special drug treatment. The only available methods are long-acting medroxyprogesterone acetate injection or oral medroxyprogesterone acetate. These are not medicines for self-use and must be treated scientifically in the endocrinology department of a large hospital.

3. Parents should pay special attention to their children’s psychological changes: after a clear diagnosis, tell the child some necessary knowledge to help her adapt to the new changes in her body and prevent bad people from taking advantage of the child’s young age and ignorance to do bad things. At the same time, you should also be mentally prepared, because there is a lack of effective treatment for some cases of precocious puberty, which requires even more careful care from parents.

4. Drug treatment: Gonadotropin-releasing hormone analogue GnRHa

The first dose is 80-100ug/kg. For those who have menarche, the dose should be boosted once after 2 weeks, and then once every 4 weeks (not more than 5 weeks) at a dose of 60-80ug/kg. The dose needs to be individualized according to the suppression of gonadal axis function, including sexual characteristics, sex hormone levels and bone age progression. Those with poor suppression can refer to the first dose. The maximum dose is 3.75mg/time. During the treatment, check the secondary sexual characteristics and measure the height every 2 to 3 months. At the end of the first dose, check the GnRH stimulation test 3 months later. If the LH stimulation value is at the pre-pubertal value, it means that the dosage is appropriate. Thereafter, for girls, only the basal serum estradiol concentration or vaginal smear maturation index needs to be checked regularly, and for boys, the basal serum testosterone level needs to be checked to determine the inhibition of gonadal axis function. Bone age should be checked once every 6 to 12 months, and girls should also have their uterus and ovaries checked by B-ultrasound.

The above is the treatment method for precocious puberty in girls. After the above introduction, everyone has a certain understanding of this. If you find that your child has this symptom, you might as well treat your child according to the above method. I hope the above information can help everyone.