Popularization of knowledge about Henoch-Schonlein purpura nephritis in children

Children's physical fitness is worse than ours, so they can easily get sick. For example, there is a disease called Henoch-Schönlein purpura nephritis, which you may not have heard of. Henoch-Schonlein purpura nephritis is a pediatric kidney disease that can lead to renal failure in its most severe form. The editor thinks that everyone should know some knowledge in this area, so he specially popularizes some knowledge about Henoch-Schönlein purpura nephritis to everyone.

According to different classification standards, there are three classification methods for childhood purpuric nephritis: ① Clinical classification of childhood purpuric nephritis, which is mainly based on the common clinical symptoms of children with purpuric nephritis; ② Pathological classification of childhood purpuric nephritis, which is mainly based on pathological changes after light microscopy of renal biopsy; ③ Immunopathological classification of childhood purpuric nephritis, which is mainly based on the deposition of immune complexes after fluorescent examination of renal biopsy.

Causes

Purpura nephritis is a partial clinical manifestation of Henoch-Schonlein purpura. Renal symptoms may occur at any stage of the course of Henoch-Schonlein purpura, but most of them appear 2 to 4 weeks after Henoch-Schonlein purpura. They may also appear after the rash subsides or in the dormant stage of the disease. The main manifestations are macroscopic hematuria or microscopic hematuria and proteinuria.

treat

There is currently no specific treatment for purpuric nephritis in children. Symptomatic treatment is the main treatment, with attention paid to protecting renal function.

1. Lightweight

No special treatment is required, and symptomatic and supportive treatment is the main approach, avoiding contact with allergy-causing foods and drugs. Sensitive antibiotics can be used when there is clear infection.

2. Acute nephritic syndrome

The main functions are to lower blood pressure, promote diuresis, control infection foci, and protect kidney function. Specific medication is the same as that for acute glomerulonephritis.

3. Nephrotic syndrome

Adrenal cortical hormones can be used, usually prednisone.

4. Rapidly progressive nephritis and chronic nephritis

The treatment is usually combined with hormones, cytotoxic drugs, anticoagulants and traditional Chinese medicine. Renal failure can be treated with dialysis. For rapidly progressive nephritis, methylprednisolone pulse therapy can be used early.

Prognosis

More than half of children with Henoch-Schonlein purpura can recover from kidney damage on their own, but a small number of children still have persistent hematuria, proteinuria and hypertension for a long time. About 2% of children develop end-stage nephritis, especially those with glomerulonephritis showing crescent formation in pathological examination. More than 80% of them develop end-stage nephritis within 1 year.

The above is some relevant knowledge about Henoch-Schönlein purpura nephritis that the editor wants to share with you. I hope it will be helpful to you. Dear parents, if your baby suffers from Henoch-Schonlein purpura nephritis, don’t worry too much. As long as it is treated in time, the baby will not have too many problems. I wish your baby good health.