An expanded introduction to rheumatoid arthritis in children

Not only adults can suffer from rheumatoid arthritis. In many cases, because children do not actively keep warm in their daily lives, they are invaded by cold air and can easily cause rheumatoid arthritis in children. Children usually feel pain in their legs and redness and swelling in their joints. Next, I will introduce in detail how to deal with rheumatoid arthritis in children.

The pathological changes of this disease are mainly joint lesions. It is a chronic non-suppurative synovitis. In the early stage, the synovial membrane of the joint is congested and edematous. Accompanied by infiltration of lymphocytes and plasma cells. The synovial effusion increases and the synovial membrane proliferates to form villous protrusions in the joint cavity. The synovitis continues to progress and enters the late stage. Synovial villous hyperplasia involves articular cartilage. And form pannus. Cartilage can be absorbed. Subchondral bone is eroded. Subsequently, the joint surfaces adhere to each other and the joint cavity is replaced by fibrous tissue. Cause joint stiffness, deformity or subluxation.

Joint destruction rarely occurs in children with rheumatoid arthritis. Nonspecific fibrinous serositis may occur in the pleura, pericardium, and peritoneum. The histological changes of rheumatoid rash are subepithelial small vessel vasculitis. The cause of this disease is still not fully understood. The pathogenesis is generally believed to be related to immunity, infection and genetics. It seems to be a type III allergic reaction, causing damage to connective tissue. It may be due to infection with microorganisms (bacteria, mycoplasma, viruses, etc.) that continuously stimulates the body to produce immunoglobulins. Serum IgA, IgM, and IgG increased. Antinuclear antibody titers were elevated in some patients. Rheumatoid factor exists in the patient's serum. It is a macroglobulin, that is, IgM with a sedimentation coefficient of 19S, which can react with denatured IgG to form an immune complex. Deposited in the synovium of joints or blood vessel walls through activation of the complement system. and release from lysosomes of granulocytes and large monocytes. Causes inflammatory tissue damage. The complement levels in the patient's serum and synovium were decreased, while IgM, IgG and immune complexes were increased. This suggests that this disease is an immune complex disease.

When it comes to children with rheumatoid arthritis, friends should actively take care of their children to prevent the invasion of cold air from making rheumatoid arthritis worse, especially in terms of diet. Children should be reminded that patients with rheumatoid arthritis should not eat seafood.