What is the cause of corpus callosum agenesis?

The emergence of diseases can cause serious damage to our bodies. Corpus callosum dysgenesis is a serious phenomenon. Maybe everyone does not have much knowledge about this disease and does not understand what kind of disease it is. What is the cause of corpus callosum dysgenesis? Let us learn together today and let us understand it through the article.

Agenesis of the corpus callosum is a rare disease in children. Hypoplasia of the corpus callosum may result in mild intellectual disability, mild visual impairment, or crossed tactile localization disorder. In severe cases, mental retardation and epilepsy may occur. Increased intracranial pressure may occur due to hydrocephalus. Infants often present with spasms and pyramidal tract signs.

The corpus callosum is hypoplastic or absent since Rell's autopsy report in 1812, and has been described in detail by Bull (1967) and Brun (1973). Agenesis of the corpus callosum may be complete or partially absent. The most common finding is complete agenesis of the corpus callosum and hippocampal commissure, while the anterior commissure is preserved. Of the fiber bundles preserved in the corpus callosum, only the Probst bundle is a bundle of fibers that projects in an anteroposterior direction and does not cross the midline. Because there is no binding force of the corpus callosum fibers. The roof of the third ventricle is raised dorsally. The interventricular foramen is significantly enlarged, forming a "bat"-shaped cystic cavity between the third ventricle and the lateral ventricle. The posterior horn of the lateral ventricle expands toward the medial direction. In partial agenesis of the corpus callosum, the splenium is most commonly absent, but any part of the body and mouth may be affected.

Agenesis or absence of the corpus callosum combined with other brain malformations, including heterotopia, cerebral aqueductal stenosis, and hypoplastic or absent septum pellucidum. Agenesis of the fornix, arachnoid cyst, Chiari malformation, Dandy-Walker syndrome, Aicardi syndrome, microgyria, schizencephaly, cranial nerve agenesis, brain perforation malformation, hydrocephalus, encephalocele, cyclops, olfactory agenesis, holoprosencephaly, microcephaly, hypergyria, septo-optic dysplasia, interhemispheric fissure cyst, brain atrophy, trisomy 13, 14, 15, 18 and corpus callosum lipoma, etc.

After reading the introduction of the article, everyone must know what corpus callosum dysgenesis is and what the cause of corpus callosum dysgenesis is. This disease is a rare disease in children, but the harm cannot be ignored. It must be discovered and treated in time. Now that everyone understands the cause of its occurrence, we must help children prevent this disease in time.