Causes of scleroderma in children

I believe that everyone is not too familiar with diseases like scleroderma. Scleroderma is not a common disease, but because scleroderma is very harmful, we still need to learn more about scleroderma. Scleroderma not only occurs in adults but also in children. So what exactly causes children to suffer from scleroderma? Below we introduce the causes of scleroderma in children.

Scleroderma refers to a skin hardening disease. The degree of skin hardening varies with the severity of the patient's condition. Mild cases only have local skin hardening, while severe cases will have widespread skin hardening throughout the body, even endangering the health of other organs in the body. Knowing the serious harm of scleroderma, we should pay attention to prevention in daily life. Scleroderma affects a wide range of people. Not only adults should prevent this disease, but children should also be wary of the invasion of scleroderma.

1. Heredity: This is a common cause of scleroderma. In patients with scleroderma, the expression of certain HLA-II class antigens is significantly higher than that in normal people. This cause of scleroderma is relatively common.

2. Immune abnormalities: This disease involves abnormalities in humoral immunity and cellular immunity, and specific anti-Scl-70 autoantibodies can be detected in the patient's serum. This shows that the cause of scleroderma is closely related to immune disorder.

3. Abnormal connective tissue metabolism: The characteristic change of this disease is excessive production of collagen, and the collagen content in the skin increases significantly.

4. The role of cytokines: Certain cytokines are involved in the pathogenesis of this disease, such as transforming growth factor, epidermal growth factor, platelet-derived growth factor, etc.

5. Chemicals and drugs: People who are exposed to chemicals and some antibiotics for a long time, or people who are exposed to or take antibiotics for a long time will cause fibrosis and scleroderma of internal organs, which is also a cause of scleroderma.

In the above article, we introduced a relatively rare disease, that is, scleroderma. We know that children may also suffer from scleroderma, so we must help children prevent scleroderma. The above article introduces in detail the causes of scleroderma in children.