Six reference values ​​of sex hormones in children

Many people, when seeing the six-item sex hormone test report of children, think that it is normal as long as the values ​​are within the normal range, but this is completely wrong. What are children's sex hormones? Sex hormones, also known as hormones, are male hormones that begin to be secreted in large quantities by children after male puberty. They dominate the development and maturation of male reproductive organs, the development of secondary sexual characteristics and maintain their normal functions. So what are the six reference values ​​for children's sex hormones?

1. Luteinizing hormone (hLH)

Reference range: Adult male: 1.24-8.62 Female: Follicular phase: 2.12-10.89 Ovulation phase: 19.8-103.3 Luteal phase: 1.20-12.86 Menopausal phase: 10.87-58.64

2. Follicle-stimulating hormone (hFSH)

Reference range: Adult male: 1.27-12.96 Female: Follicular phase: 3.85-8.78 Ovulation phase: 4.54-22.51 Luteal phase: 1.79-5.12 Menopausal phase: 16.74-113.5

3. Prolactin (PRL) Male : 2.64-13.13 Female: <50 years old 3.34-26.72 >50 years old 2.74-19.64

4. Progesterone (Prog) Male: 0.10-0.84 Female: Follicular phase: 0.31-1.52 Luteal phase: 5.16-18.56 Menopausal phase: 0.08-0.78

5. Estradiol (ESTRDL) Male: 20-75 Female: Follicular phase: 24-114 Luteal phase: 80-273 Menopausal: 20-88

6. Testosterone (TESTO) Male: 176-789 Female: Follicular phase: 10-75

1. The FSH value on the third day of menstruation is generally 5.8. The LH value is 4.8. This is more normal.

2. The normal value of estrogen (E2) on the third day of menstruation should be between 62 and 70. If E2 is <50pg/ml, it means that the endometrium is not adequately prepared for estrogen, the estrogen level is low, and there will be obvious clinical symptoms.

3. When estrogen is low, PRL will be high, and when you are nervous during the test, PRL will also increase. This is a physiological increase. If it is not caused by pituitary microadenoma, there is no need to take Xiyinting.

Generally, there is no need to test progesterone (P) on the third day of menstruation. It can be tested on the 22nd day of menstruation (or the 7th day of ovulation), which is both cost-effective and meaningful.

Combined determination of follicle stimulating hormone (FSH) and luteinizing hormone (LH)

1. Increased FSH and LH are common in primary gonadal lesions, such as premature ovarian failure, gonadal dysgenesis, primary amenorrhea, primary sexual dysfunction, seminiferous tubule development disorders, and complete (true) precocious puberty.

2. Decreased FSH and LH levels are mainly seen in pituitary or hypothalamic amenorrhea and incomplete (pseudo) precocious puberty.

3. Patients with pituitary FSH tumors, LH tumors, and FSH/LH tumors have different types of changes in serum FSH and LH concentrations due to different adenoma types: FSH tumors are mainly manifested by increased FSH, while LH may be normal; in LH tumors, LH is significantly increased, while FSH is decreased; in FSH/LH tumors, both FSH and LH are increased.

4. Testing the FSH and LH concentrations in women with amenorrhea can effectively differentiate between ovarian amenorrhea and pituitary or hypothalamic amenorrhea. It is generally believed that low LH (<51U/L) is a more reliable indicator of insufficient GTH secretion by the pituitary gland, while high FSH (>40IU/L) is a more reliable indicator of ovarian failure. If high FSH is accompanied by high LH, it can be reliably confirmed as ovarian failure. If serum FSH and LH are both abnormally low or FSH is at the lower limit of normal and LH is abnormally low, it can be diagnosed as pituitary or hypothalamic amenorrhea. Subsequently, a pituitary stimulation test using luteinizing releasing hormone (LRH) can be used to further distinguish between pituitary and hypothalamic amenorrhea: the stimulation test shows an increase in LH and FSH with a delayed peak, indicating that the pituitary reserve function is good and hypothalamic amenorrhea should be considered; if LH and FSH have weak reactions, it indicates that the pituitary reserve function is low and pituitary amenorrhea should be considered. In summary, multiple indicators can be combined to analyze the lesion site of amenorrhea.

ProjectFollicular phaseOvulation phaseLuteal phase

Follicle-stimulating hormone 3.85~8.78 4.54~22.51 1.79~5.12

Luteinizing hormone 2.12~10.89 19.18~103.03 1.20~12.86

Progesterone 0.31~1.52 3.3~25.6 5.16~18.56

Estradiol 24~114 150~528 80~273

Prolactin 3.34~26.72 (the values ​​in the three periods are the same, and this value is the normal value for those under 50 years old)

Testosterone 0.1~0.9 (the values ​​are the same in the three periods)