What is the cause of low platelet count in children?

Children are prone to low platelet count, which is very harmful to their health. The most common ones are aplastic anemia or acute leukemia, which are closely related to the child's own immune deficiency. In addition, low platelet count can also be easily caused by the influence of external chemical substances, such as new decoration in the home, etc. In addition, drugs are also an important reason.

1. Low platelet count in children may be due to defects in the human immune system

Low platelet count in children may be caused by defects in the human immune mechanism and an imbalance in the immune system, which is medically known as immune thrombocytopenia. There are many factors that can trigger this disease, including chemical poisons, radiation, ionizing radiation, vaccinations, inflammatory viral infections, drugs, excessive fatigue, etc. These factors can only be speculated and it is impossible to determine what exactly caused it.

Mainly, these inducing factors have no direct relationship with treatment. For example, if the patient is caused by long-term exposure to chemical toxins, the important thing is to cure the root cause and prevent recurrence. If it is cured, it will not be affected by any factors and recur.

2. Low platelet count in children may be caused by medication

1. Drugs that cause low bone marrow regeneration or disorder accompanied by pancytopenia. Chemical substances and drugs that can easily cause bone marrow hypoplasia at a certain dose: ① Benzene, xylene, etc. ②Alkylating agents: such as nitrogen mustard, cyclophosphamide, phenylpropionate mustard, etc. ③Antimetabolites: such as cytarabine, mercaptopurine, etc. ④Anti-cancer antibiotics: such as doxorubicin, adriamycin, etc. ⑤Others: such as organic arsenic, etc.

2. Drugs that can cause bone marrow aplasia or hypoplasia: such as chloramphenicol, sulfonamides, penicillin, streptomycin, Xinqing No. 1, trimethadione, phenytoin sodium, ethosuximide, antithyroid drugs (such as thiouracil, propylthiouracil, thyroxine), diabetes drugs (such as tolbutamide, chlorbutamide, chlorpropamide, etc.), phenylbutazone, indomethacin, tranquilizers and sedatives (tranquilization, chlordiazepoxide, chlorpromazine, etc.), gold preparations, hair dyes, promethazine, chlorpheniramine, acetazolamide, etc.

3. Drugs that selectively inhibit the production of platelets by megakaryocytes: such as chlorothiazide, estrogens, ethanol, tolbutamide, ristocetin, etc.

3. Low platelet count in children may be caused by antibodies

Low platelet count in children may also be caused by antibodies (biochemical substances with protective effects) formed by the body attacking its own platelets. Certain acute infections are the root cause of this disease. Too much blood transfusion in a short period of time (such as during major surgery), or abnormal bleeding and clotting may cause thrombocytopenia.