Causes of congenital choledochal cyst in children

People who suffer from congenital common bile duct cyst in children think that it is a minor illness and does not require treatment. People don’t think of treating congenital bile duct dilatation until the condition becomes serious. So, what is the cause of congenital common bile duct cyst in children? The editor will introduce it to you below, hoping it can help you.

The cause of congenital common bile duct cyst in children is still controversial. With the progress of morphological, bile enzymology and animal experimental research in the past decade, we have a deeper understanding of its cause. Most scholars believe that this disease is related to congenital abnormal bile and pancreatic duct junction and distal common bile duct obstruction.

1. Congenital malformation of the pancreaticobiliary junction

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2. Biliary tract dysplasia

During the embryonic period, the proliferation of primitive bile duct epithelial cells is unbalanced. For example, excessive proliferation at the distal end will cause stenosis at the distal end and expansion at the proximal end during cavitation, resulting in this disease. The common bile duct wall is congenitally deficient in elastic fibers, and when the intra-biliary pressure increases, it gradually expands, and there is no obstruction at the distal end.

3. Viral infection

In recent years, through tissue pathological changes, it has been found that hepatitis B virus, cytomegalovirus, adenovirus, etc. can cause obstruction of the bile duct lumen or weakening of the bile duct wall, resulting in bile duct deformity.

4. Abnormal nerve distribution

Some scholars have detected the nerve distribution of the common bile duct in infants and fetuses, and compared it with the distribution of ganglion cells in the distal narrow segment of children with common bile duct dilatation. The number of nerve fiber bundles and ganglion cells in the narrow segment of the children was significantly reduced compared with the control group. Therefore, it is believed that the occurrence of common bile duct dilatation is related to the abnormal distribution of the distal common bile duct nerve plexus and ganglion cells. However, whether the reduction of ganglion cells and abnormal nerve development are congenital lesions or acquired secondary lesions requires further study.

The above is an analysis of the causes of congenital common bile duct cysts in children. Only after understanding these can we better treat them. For children with congenital common bile duct cyst, they should pay attention to personal hygiene and diet at all times.