Symptoms of hemolytic uremic disease in children

Hemolytic uremic disease is a malignant disease that can occur at any age. The disease can cause great harm to people's bodies and requires us to actively treat it. Hemolytic uremic disease in children is a relatively common disease. When the patient is ill, he will experience loss of appetite, vomiting and fever. We need to always pay attention to the changes in children and seek medical treatment in time. Let's take a look at the symptoms of hemolytic uremic syndrome in children.

There are many symptoms when hemolytic uremic disease occurs in children. Children will have persistent anemia and thrombocytopenia. If the disease is not controlled in time, acute renal failure will occur, which requires our attention.

What are the symptoms of hemolytic uremic disease in children? 1. Prodromal symptoms Typical patients have prodromal symptoms. The main manifestations are gastrointestinal symptoms, such as loss of appetite, vomiting, diarrhea, abdominal pain, accompanied by moderate fever. A few have severe bloody stools. 1/3 of children have symptoms of upper respiratory tract infection. This period usually lasts 1 to 7 days, and then after a 1 to 5 day asymptomatic period, it enters the acute phase.

2. Acute phase manifestations Typical findings in the acute phase are hemolytic anemia, thrombocytopenia and acute renal failure.

(1) Hemolytic anemia: Hemolytic anemia is characterized by a significant decrease in hemoglobin in a short period of time. The degree of anemia is inconsistent with the severity of acute renal failure. Children show pale complexion, jaundice is generally not obvious, or only the face is lemon yellow. Hemolytic crises may occur repeatedly within the first 2 weeks of the disease, and hemoglobin can drop by 30 to 50 g/L within a few hours. Peripheral blood examination shows increased white blood cells and reticulocytes, and blood smears may reveal abnormally shaped red blood cells and red blood cell fragments. The red blood cells may be triangular, armor-shaped, or thorn-shaped. Elevated blood unconjugated bilirubin. The life span of red blood cells is shortened to an average of 3 days. Anemia gradually recovers after 1 to 3 weeks.

(2) Thrombocytopenia: 90% of patients suffer from thrombocytopenia, which is mainly caused by increased peripheral destruction. The platelet survival time is shortened from the normal 7 to 10 days to 1.5 to 5 days. Thrombocytopenia generally lasts for 7 to 14 days, and in a few cases recovery is slower. Due to thrombocytopenia, there is a bleeding tendency, which manifests as nose bleeding, bleeding gums, skin petechiae or small hematomas, vomiting blood, blood in the stool, hemoptysis, fundus hemorrhage, and even cerebral hemorrhage.

The above content is an introduction to the symptoms of hemolytic uremic disease in children. I hope it can be of some help to you. In the later stages of the disease, many complications will appear. People will develop mental illnesses, and it will cause certain harm to children's hearts, causing arrhythmias, which can even be life-threatening in severe cases.