Neutropenia in children

Children are particularly prone to childhood neutropenia when they are young. This disease is generally caused by cell reduction. It is divided into familial and congenital. It can be seen that it has genetic factors, and it is generally intermittent when it occurs. It is the most fundamental element leading to blood diseases. So how should childhood neutropenia be treated?

Pseudogranulocytopenia is caused by abnormal distribution of granulocytes. The fluctuation range of granulocytes in the patient's peripheral blood is large and changes rapidly. Those with no primary disease or recurrent infection can be collectively referred to as benign granulocytopenia, including familial, congenital and pseudogranulocytopenia. The attacks were intermittent, with moderate granulocytopenia and a good course. When blood flow slows down, granulocytes tend to adhere to the walls of small blood vessels, resulting in an increase in the number of granulocytes in the marginal pool. After injection of epinephrine, the granulocyte count may increase to normal or to 1 to 2 times the count before the test, which can be used as a basis for diagnosing the disease.

Causes

Generally speaking, secondary neutropenia is more common and primary neutropenia is rare. Predisposing factors include:

1. Genetic factors

An autosomal dominant tendency has been found in some families.

2. Infection

Bacterial infections, such as typhoid, paratyphoid, brucellosis, miliary tuberculosis, severe sepsis, etc.; viral infections, such as influenza, measles, rubella, viral hepatitis, etc.; protozoan infections, such as malaria, kala-azar; rickettsial infections, such as typhus, etc.

3. Physical and chemical damage

Ionizing radiation, such as X-rays and radionuclides; chemicals, such as lead, benzene, mercury, etc.; drugs, such as aminopyrine drugs, anticancer drugs, chloramphenicol, etc.

4. Blood diseases

Aplastic anemia, acute leukemia, myelodysplastic syndrome, megaloblastic anemia, etc.

5. Autoimmune diseases

Systemic lupus erythematosus, rheumatoid arthritis, Felty syndrome, chronic active hepatitis, neonatal alloimmune neutropenia, pure granulocytic aplasia, etc.

6. Hypersplenism

Cirrhosis of the liver, malaria, chronic hemolytic anemia, advanced schistosomiasis, kala-azar, primary splenic neutropenia, etc.

7. Others

Emotional changes, exercise, and changes in body temperature can all lead to abnormal distribution of granulocytes.