Commonly used medicines for children's cough

Cough is a common health problem among children. When children have a cough, they need to be taken to the hospital for treatment in time. If they cannot go to the hospital, they need to buy medicines that can treat children's cough for their children. There are many medicines that can treat children's cough, the more common ones are acyclovir, ganciclovir and interferon.

Acyclovir is an acyclic purine nucleotide analog. Its antiviral effect is that after the drug enters the cells infected by the herpes virus, it competes with deoxynucleoside for viral thymidine kinase or cellular kinase. The drug is phosphorylated into activated acyclovir triphosphate, which then inhibits viral replication in two ways:

① Interfere with the polysaccharide of viral DNA and inhibit viral replication;

② Under the action of DNA polysaccharides, it binds to the growing DNA chain, causing the extension of the DNA chain to be interrupted. The therapeutic dose is 20 MG/KG, added to 100 mL of 10% glucose solution and dripped intravenously, once a day; or oral acyclovir 5-10 MG/(KG·D), 3 times a day. Acyclovir, as a highly effective and broad-spectrum antiviral drug, can significantly shorten the fever and skin lesion healing time, relieve the pain of oral herpes, and no side effects are observed during the treatment.

2. Ganciclovir

Ganciclovir, also known as ganciclovir, is a newly developed broad-spectrum nucleoside antiviral drug after acyclovir. The antiviral effect is similar to that of acyclovir. The therapeutic dose is 5-10 MG/KG, added to 100 mL of 10% glucose solution and dripped intravenously, once a day, for a course of 3-5 days. Antibiotics and antipyretics should be used as appropriate during medication. Studies have shown that ganciclovir is more effective than ribavirin in treating cough in children, and the time it takes for fever and herpes to subside is significantly shorter than that of ribavirin.

However, the inhibitory effect of ganciclovir on the bone marrow and its long-term toxic side effects need further study.

3. Interferon

As a powerful antiviral agent, interferon has significant therapeutic effects on a variety of viral infectious diseases and has been widely used in clinical practice. The therapeutic dose is 1 million IU intramuscular injection, once a day. Its therapeutic mechanism is to prevent viral replication by blocking the translation of viral MRNA in cells and inhibiting viral ribonucleic acid synthesis. It can also enhance host immunity by enhancing the activity of natural killer lymphocyte toxins. Adequate use of interferon can enhance the body's cellular immunity, thereby inhibiting viruses and promoting the body's recovery. Research by Hu Gong et al. showed that interferon combined with traditional Chinese medicine preparations such as Xiaoer Qingrening has obvious therapeutic effect in treating children's cough.