Eosinophils in children

Alkaliphils are a type of white blood cell that originate from hematopoietic pluripotent stem cells in the bone marrow and enter the bloodstream after differentiation and maturation in the bone marrow. The cell body of alkaliphilic granulocytes is round, with a purple-red cytoplasm containing a small number of coarse but unevenly sized and irregularly arranged black-blue alkaliphilic granules, which often cover the nuclear surface. An increase in the number of alkaliphils is often seen in certain allergic diseases, certain blood diseases, certain malignant tumors and certain infectious diseases. This indicator will appear in some test reports, so let us understand why children’s eosinophil levels are high!

White blood cells are a type of cell in the blood. When pathogens invade the human body, white blood cells can deform and pass through the capillary walls, concentrate at the site of invasion, surround and engulf the pathogens. If the number of white blood cells in your body is higher than normal, it is likely that your body has inflammation. Normal mature white blood cells in the human body can be divided into five categories: neutrophils, eosinophils, alkaliphils, lymphocytes and monocytes.

1. Increase

(1) Allergic diseases: Allergic colitis, hypersensitivity reactions to drugs, food, inhalants, erythema and rheumatoid arthritis can be seen in the increase of alkaliphilic granulocytes.

(2) Hematological diseases such as chronic myeloid leukemia, myelofibrosis, alkaliphilic leukemia, chronic metastatic cancer and Hodgkin's disease are often accompanied by an increase in the number of alkaliphils. In addition, an increase in the number of alkaliphils can also be seen in chronic hemolysis and after splenectomy.

(3) The number of alkaliphils increases in malignant tumors, especially metastatic cancer, but the mechanism is unclear.

(4) Other diseases such as diabetes, infectious diseases such as chickenpox, influenza, smallpox, and tuberculosis can all be associated with an increase in the number of alkaliphilic granulocytes.

2. Reduce

The reference value of alkaliphils in peripheral blood is very low, so a decrease in their number has no clinical significance.

Normal reference range

1. The percentage of alkaliphilic granulocytes to the total white blood cell count: 0.03-0.08.

2. Absolute value of alkaliphilic granulocyte count: (0.12～0.8)×109/L.