What is the cause of delayed myelin development in the white matter?

What is the cause of delayed myelin development in the white matter?

The brain is a complex organ, composed of various strange substances and structures, which plays a role in coordinating and directing various functions of people. Therefore, people without a brain cannot survive at all. The development of the most important part of the brain, such as the white matter myelin sheath, is very critical to health. Let's take a look at what is the delay in the development of the white matter myelin sheath?

Delayed myelination is a myelin abnormality that usually affects the white matter. Myelination is the final stage of white matter development. Myelination begins in the fetus from the third to sixth month in utero, starting from the spinal nerve roots and spinal cord, and developing from the caudal to the cephalic side. At birth, there is already a considerable amount of myelin located in the brainstem, pontine arms, posterior limb of the internal capsule, and corona radiata of the centrum semiovale. Its maturation process mainly occurs after birth and continues until the age of 20, and the myelin sheath of the white matter of the brain is remodeled throughout life.

reason

If children are affected by certain secondary factors such as viral infection, suffocation, poisoning, autoimmune disease, etc., or certain primary factors such as multiple sclerosis, Schilder's disease, etc., they will develop demyelinating lesions. Demyelination has a significant impact on the development of the child's nervous system, often leading to disabilities such as mental retardation, epilepsy, language disorders, and limited mobility. MRI is helpful for diagnosis.

examine

Diagnosis: The clinical manifestations of leukodystrophy are characterized by gradual progression, and early symptoms are often easily overlooked. Originally normal infants or children may gradually experience changes in muscle tone, posture, movement, gait, language, eating movements, vision, memory and learning, behavioral thinking abilities, etc. These symptoms may gradually worsen, and the disease progresses faster in children.

Mitigation methods

1. Provide targeted treatment based on the cause of the disease. Symptomatic treatment can include rehabilitation exercises, acupuncture and physical therapy, and the use of neurotrophic agents such as B vitamins, Nootropics, and Noofukang drugs.

2. Prevention of the occurrence of the disease should start from the embryonic period, with regular B-ultrasound examinations. Pregnant women with high-risk factors should undergo Down syndrome screening and four-dimensional color ultrasound examinations. If the fetus is found to be abnormal, the pregnancy will be terminated in a timely manner.

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