What is the reason for high alkaline phosphatase in children?

When children have high alkaline phosphatase levels, we need to pay attention to the causes. Common obstructive jaundice, cirrhosis, liver necrosis, and other tumor problems may show symptoms of high alkaline phosphatase levels.

1. In obstructive jaundice, cirrhosis, and liver necrosis, alkaline phosphatase is significantly elevated (in hepatocellular jaundice, the elevation is not significant).

2. Alkali phosphatase levels are also significantly elevated in primary and secondary liver cancer, which is related to the increased synthesis of alkaline phosphatase by hepatocytes in cancer tissue or around the tumor.

3. For other tumors such as breast cancer, lung cancer, ovarian cancer, osteoblastoma, osteosarcoma, etc., when alkaline phosphatase increases, it indicates possible liver metastasis.

4. Osteitis deformans, osteoblastic carcinoma, rickets, osteomalacia, hyperthyroidism and hyperparathyroidism, renal tubular acidosis, hereditary hyperphosphatase

5. Many drugs can increase alkaline phosphatase, such as barbiturates, antibiotics (erythromycin, gentamicin, chloramphenicol, kanamycin, ampicillin, etc.).