How to treat purpuric nephritis in children

Purpura nephritis in children is a systemic disease that is a necrotizing inflammation of the small vessels. In addition to affecting the kidneys, purpuric nephritis may also affect other organs of the body. After becoming ill, the child's skin may show purpura symptoms all over the body, and the child may also have abdominal pain and joint pain. Some children with purpuric nephritis may not show any symptoms, and the disease is often not taken seriously until the rash appears.

There is currently no specific treatment for purpuric nephritis in children. Symptomatic treatment is the main treatment, with attention paid to protecting renal function. Mild cases do not require special treatment, and are mainly symptomatic and supportive, with avoidance of allergic foods and drugs. Sensitive antibiotics can be used when there is clear infection. The acute nephritic syndrome type is mainly treated by lowering blood pressure, promoting diuresis, controlling infection foci, and protecting renal function. Specific medication is the same as that for acute glomerulonephritis. For nephrotic syndrome, adrenal cortical hormones can be used, usually prednisone. Rapidly progressive nephritis and chronic nephritis are often treated with a combination of hormones, cytotoxic drugs, anticoagulants and traditional Chinese medicine. Renal failure can be treated with dialysis. For rapidly progressive nephritis, methylprednisolone pulse therapy can be used early.

More than half of children with Henoch-Schonlein purpura can recover from kidney damage on their own, but a small number of children still have persistent hematuria, proteinuria and hypertension for a long time. About 2% of children develop end-stage nephritis, especially those with glomerulonephritis showing crescent formation in pathological examination. More than 80% of them develop end-stage nephritis within 1 year.

Generally speaking, the prognosis of purpuric nephritis in children is good, but a small number of children have a poor prognosis and have varying degrees of proteinuria. Allergy is the most common cause of purpura nephritis in children, so parents should pay attention. Once they find a substance that causes their children to be allergic, they should try to avoid their children's contact in the future, and they should remind their children not to come into contact with such substances that may cause allergies in their daily lives.