Causes of high platelet count in infants and young children

Low platelet count is the first relatively abnormal phenomenon, and it is also a phenomenon that exists in many infants and young children. When low platelet count occurs, it is important to conduct a prompt examination to determine what problems exist in the child's body. The earlier you discover the problem, the earlier you can solve it, thus preventing yourself from developing more serious illnesses. So, what are the causes of high platelets?

1. Common causes

There are many causes of thrombocythemia, and blood stasis is one of the factors that lead to this disease. Blood stasis can be caused by factors such as cold stagnation, qi stagnation, qi deficiency, heat evil, yin deficiency, and liver depression. G6PD isoenzyme examination confirms that thrombocythemia is also a clonal disease of pluripotent stem cells, which leads to a continuous and significant proliferation of bone marrow megakaryocytes, increased platelet production, and the release of stored platelets in the spleen and liver, but the lifespan of platelets is mostly normal.

2. Spleen damage

The pathogenesis of thrombocythemia is mainly due to platelet function defects, decreased adhesion and aggregation function, decreased platelet factor III, decreased serotonin and abnormal release function. Some patients also have abnormal coagulation mechanism and increased capillary fragility. Excessive platelet activation will produce thromboxane, which will easily cause platelet aggregation and release reaction, thereby forming thrombus in the microvessels. Late-stage patients will also have extramedullary hematopoiesis in the spleen and other organs.

3. Disease factors

There are many factors that can cause thrombocythemia, including malignant tumors including hematological malignant diseases; chronic inflammation including connective tissue diseases, tuberculosis, cirrhosis, chronic pancreatitis, chronic pneumonia, arteritis; acute inflammatory infection; acute blood loss; iron deficiency anemia; hemolytic anemia, etc. can all cause thrombocythemia and damage people's bodies.

4. The spleen destroys platelets

In thrombocythemia, the number of megakaryocytes and the average megakaryocyte capacity are increased, and platelet production can reach 15 times the normal rate. In most cases, the lifespan of platelets is normal. In a few patients, the shortening may be due to spleen destruction of platelets. Moreover, the mechanism by which a large increase in platelets leads to bleeding and thrombosis is not certain. It is generally believed that abnormal platelet function is the main cause of bleeding, and a decrease in coagulation factors in some patients is also a major factor in bleeding. People are reminded to take scientific preventive measures in a timely and accurate manner.

5. Family causes

Since chromosomal dominant genetic diseases, mutations in the TPO gene and increased thrombopoietin are relatively rare, it also indicates that the occurrence of thrombocythemia in some cases may be related to people's family history of the disease. It also reminds people to be familiar with whether there are members of their family suffering from this disease, so that people can take timely measures to prevent it.