Treatment of high platelet count in children

A child's high platelet count is not good for his or her health. Therefore, for many parents, when they find out through hospital examination that their child has a high platelet count, in order to protect the child's health from being harmed, they must receive treatment as soon as possible so that the child can recover as soon as possible. The following introduces the treatment methods. For many parents, they can receive treatment as soon as possible through the following treatment methods.

1. Platelet removal is also called platelet collection. It is suitable for patients with acute onset, severe condition, and embolic or bleeding complications. The purpose is to quickly reduce the platelet count, relieve symptoms, and continue with 32P or chemotherapy.

2. Radioactive 32P: Take 32P dibasic sodium salt orally or intravenously. The first dose is 3-4mCi (millicuries). Observe blood count regularly. If the condition does not improve within 3 months, another dose can be used. Generally, platelets begin to decrease within 1 month and reach the lowest value in 6 to 8 weeks.

3. Chemotherapy is mainly based on alkylating agents.

(1) Hydroxyurea: Currently the first choice, it has no reports of causing treatment-related leukemia. It is safe to use, but takes a long time to take effect, about 4 weeks, and maintenance doses should be given, otherwise there will be a rebound.

(2) Busulfan (Myleran): Previously the drug of choice, it is still an effective chemotherapy drug due to the widespread use of hydroxyurea. The dosage is 4-6 mg/d. When the platelet count returns to normal, stop using the drug or maintain it at a low dose.

(3) Melphalan: 0.05 mg/(kg·d), oral administration. It can easily cause bone marrow suppression, and blood counts should be checked regularly.

(4) Chlorambucil (Chlorambucil): 0.1-0.15 mg/(kg·d). The dose should be halved when the platelet count decreases to 50%.

(5) Nitrogen mustard: Suitable for severe patients with thrombosis. The dosage is 0.4 mg/kg. Dissolve it in 20 ml of normal saline and inject it. Give a small amount of sedatives as appropriate.

4. Platelet function inhibitors such as low-dose aspirin 10 mg/(kg·d) taken orally can reduce thrombosis. Dipyridamole (persantin) 5 mg/(kg·d) orally.

5. Interferon has antiviral, anti-proliferative, immunomodulatory, differentiation-inducing, and bone marrow malignant clone-inhibiting effects. Dosage: 100-300 U/time, subcutaneous injection every other day. Discontinue use when platelet count is <400×109/L.

If you have a disease, you must seek treatment as soon as possible to recover as quickly as possible. So when your child's platelet count is high and it affects your child's health, as a parent, you must take your child through a comprehensive examination and use the treatment methods introduced above as soon as possible. Through treatment, your child's platelet count can be high, and after treatment, it can be kept normal as soon as possible.