What to do if your child's white blood cell count is high

Children's bodies develop very quickly because their metabolism develops very quickly. This rapid metabolic process is to allow children to grow up healthily. But if a child's white blood cell count is high, is it also to allow the child to grow up healthily? Is a child's high white blood cell count a sign of health or a sign of unhealthiness?

1. Causes of disease

Bacterial infection caused by decreased activity of 6-phosphate degrading enzyme in leukocytes.

2. Pathogenesis

According to the research of Bachner et al. in 1971, G-6-PD is considered to be necessary for the decomposition and metabolism of hexose monophosphate (Hexase-monophosphate) in cells. It can catalyze the dehydrogenation of hexose monophosphate to produce NADPH, which produces H202 under the action of NADPH oxidase, thereby exerting a bactericidal effect in cells. The activity of G-6-PD enzyme in neutrophils of patients with this disease is less than 25% of that of normal people (some people have confirmed that the content of this enzyme in neutrophils of patients with congenital leukocyte G-6PD deficiency is often also low, but in most patients with red blood cell G-6PD deficiency, the neutrophil G-6PD level is equivalent to 25% to 50% of that of normal people). The H202 content in its cells is also lower than 25% of that of normal people. Even though the phagocytic function of neutrophils is normal, it cannot kill bacteria. Therefore, after phagocytizing pathogens, the oxygen consumption and hexose monophosphate shunt activity will not increase, so no hydrogen peroxide will be produced.

prevention

G-6-PD and its biochemical variant "normal" enzyme are called G-6-PDB. G-6-PD deficiency is caused by abnormalities in the G-6-PD structural gene that encodes the G-6-PD amino acid sequence. Detailed biochemical studies of partially purified residual enzymes suggested that there was heterogeneity among them, and these abnormal enzymes were biochemical variants of G-6-PD. In 1966, the World Health Organization (WHO) made unified regulations on the naming, typing standards and methods of G-6-PD variants at an international conference held in Geneva. The characterization of G-6-PD is mainly based on the electrophoretic rate and enzyme kinetic characteristic parameters, such as enzyme activity, electrophoretic rate, Michaelis-Menten constant (KM) of glucose-6-phosphate (G6P) and coenzyme II (NADP), utilization rate of substrate congeners (deoxy-G6P, galactose phosphate, deaminated NADP, coenzyme I), thermal stability, and optimal pH. However, the following five items are required as a minimum: ① enzyme activity; ② electrophoretic rate; ③ G-6-PD Michaelis-Menten constant; ④ relative utilization rate of deoxy-G6P; ⑤ thermal stability.

Related diseases

1. HIV-associated respiratory tract infection (HIV-associated respiratory tract infection; human immunodeficiency virus-associated respiratory tract infection; respiratory human immunodeficiency virus)

2. Gastrointestinal infection of SARS

3. Submandibular space infection

4. Eastern equine encephalitis (EEE; Eastern equine encephalitis)

5. Severe Acute Respiratory Syndrome (SARS; Atypical Pneumonia; Severe Acute Respiratory Syndrome)

6. Neutropenia

7. Central nervous system leukemia (cerebral leukemia)

8. Aortoenteric fistula

9. Hepatitis B virus arthritis (HBV arthritis; serum hepatitis virus arthritis)

10. Galacturia

11. Chylous ascites (chylous ascites)

12. Postpartum hemorrhage

If a child's white blood cell count is too high, you should take the child to the hospital for some examinations in time, because if the child's disease is not detected for a while, it will develop very quickly, and it will be more difficult to curb the continued deterioration of the disease. Therefore, we must take good care of our children in normal times.