Treatment of nephrotic syndrome in children

Nephrotic syndrome is a disease that has a great impact on people's lives. Patients will be unable to take care of themselves and will lose the ability to survive. Such a result is of course a disaster for the family. Therefore, people are more concerned about the treatment of nephrotic syndrome. For children, the treatment of nephrotic syndrome is an important issue related to the future. Let's take a look at the methods of treating nephrotic syndrome in children.

For children who are resistant to or dependent on hormones, who have frequent relapses or recurrences, or who have obvious toxic side effects from hormone treatment, cytotoxic drugs can be used in combination. This type of drug has significant side effects, so be careful about liver damage and bone marrow suppression when using it.

1. Cyclophosphamide: 2-3 mg/kg per day, orally in 3 divided doses, total dose <300 mg/kg, treatment course <12 weeks to avoid gland damage.

2. Chlorambucil: Orally taken daily, 8 weeks as a course of treatment, total amount <14 mg/kg, and course of treatment <12 weeks.

5. Anticoagulant therapy

1. Heparin: Intravenous heparin, the dose is 1 mg/kg each time, 1 to 2 times a day, continuous intravenous drip for 2 weeks, and can be repeated if necessary. When using heparin, check blood fibrinogen, platelets and prothrombin time weekly. If bleeding tendency occurs, an equal amount of protamine can be given intravenously.

2. Others: Dipyridamole, aspirin, sodium alginate, etc. all have certain antiplatelet aggregation effects and are often used in combination with heparin.

3. Urokinase: It is often used when thrombosis occurs and is not the first choice for anticoagulation.

The principles of Traditional Chinese Medicine treatment for nephrotic syndrome in children are mainly to invigorate Qi and strengthen the spleen, warm Yang and promote diuresis. In the early stage, water and moisture are retained in the body, and emergency measures should be taken to treat the symptoms and eliminate edema. In the later stages of organ deficiency, the key to treatment is to adjust and restore the functions of the lungs, spleen, and kidneys. It is not only necessary to nourish the internal organs, but more importantly, to assist their functions, strengthen the body, and regulate yin and yang.

Child patients are very dangerous because the degree of harm of nephrotic syndrome to the human body is not limited to age. Once people suffer from nephrotic syndrome, they are likely to suffer great physical and psychological trauma, which is very detrimental to family harmony and may even cause family splits. Therefore, the treatment of child patients is particularly critical.