Clinical symptoms and western medicine treatment of hemolytic disease in children

If children suffer from hemolytic disease and do not receive effective treatment, it will cause harm to the child's health. Therefore, when many children develop hemolytic disease, their parents are particularly worried and want to fully understand the clinical symptoms and Western medicine treatment of hemolytic disease in children. In order for your child to recover as soon as possible through correct treatment, please continue to look at the following clinical symptoms and Western medicine treatment.

Clinical symptoms

The clinical manifestations of hemolytic disease of the newborn[3] vary in severity, depending on factors such as the strength of the antigen, the individual's immune response, the fetus's compensatory ability, and prenatal intervention measures. The clinical manifestations of Rh hemolytic disease are more severe and progress rapidly, while the clinical manifestations of ABO hemolytic disease are mostly milder. Rh hemolytic disease generally does not occur in the first pregnancy, but ABO hemolytic disease may occur in the first pregnancy.

Western medicine treatment

1. Plasma or albumin, which supplies albumin linked to bilirubin, can reduce free unconjugated bilirubin and prevent bilirubin encephalopathy. Plasma 25 ml/time intravenous injection (100 ml plasma contains 3 g albumin, 1 g albumin can bind to 8.5 mg unconjugated bilirubin) or albumin 1 g/kg plus 25% glucose 10-20 ml intravenous drip, 1-2 times a day.

2. Adrenal cortical hormone can prevent the reaction between antigen and antibody, reduce hemolysis, and promote the binding ability of hepatocyte glucuronyl transferase to bilirubin. Take 1-2 mg/kg of prednisone orally three times a day, or take 6-8 mg/kg of hydrocortisone daily or 1-2 mg of dexamethasone daily plus 10% glucose 100-150 ml by intravenous drip. Patients suspected of infection should use it with caution under the control of effective anti-infective drugs.

3. Enzyme inducer, which can induce the activity of glucuronyl transferase in the smooth endoplasmic reticulum of hepatocytes and reduce serum unconjugated bilirubin. Phenobarbital can also increase Y protein and promote the uptake of bilirubin by liver cells. Phenobarbital 5-8 mg/kg per day, nikethamide 100 mg/kg per day, both taken orally in 3 divided doses. Because it takes 2 to 3 days for the medication to show any effect, it is important to start taking the medication as soon as possible. Using the two drugs together can improve the efficacy.

4. Glucose and alkaline solutions. Glucose can provide calories to children, nourish important organs such as the heart, liver, and brain, and reduce metabolic acidosis. In acidosis, the blood-brain barrier opens, which increases the amount of bilirubin entering the brain tissue. Alkaline solutions should be administered in time to correct acidosis and prevent bilirubin encephalopathy. Sodium bicarbonate dose (mEq) = alkali excess × body weight (kg) × 0.3.

I believe that many parents have already fully understood the clinical symptoms of hemolytic disease in children and the treatment of Western medicine. Therefore, after fully understanding, in order to prevent this disease from causing serious damage to the child’s body structure, they should choose the Western medicine introduced above for effective treatment as soon as possible. I believe that through effective treatment, their children’s hemolytic disease will recover as soon as possible after treatment.