Treatment of neonatal hyaline membrane disease

In fact, the resistance of newborns is very poor. In addition, at the beginning, parents are not very familiar with taking care of their babies, so it may lead to the occurrence of neonatal hyaline membrane disease. Let us learn about the treatment methods of neonatal hyaline membrane disease.

Treatment:

1. General treatment

(1) Strengthen monitoring: Pay attention to keeping warm, ensure that the body temperature is between 36 and 37 degrees Celsius, and the relative humidity of the incubator is around 50%. Body temperature, respiration, heart rate were monitored with a monitor, and PaO2, PaCO2, and pH were measured transcutaneously.

(2) Keep the airway open: Clear pharyngeal mucus regularly to keep the airway open.

(3) Supportive treatment: Ensure nutrition and fluid intake. For those who cannot breastfeed, use 1/5 bottle of sodium-containing solution, 60-80 ml/(kg·d), and 100-120 ml/(kg·d) after the second day, by intravenous drip. For those using artificial respirators, if the inhaled air is saturated with water vapor, the amount of fluid replacement should be reduced to 50-60 ml/(kg·d).

(4) Oxygen therapy: Oxygen inhalation and mechanical respiration maintain PaO2 at 6.7-9.3 kPa (50-70 mmHg). Too high PaO2 can lead to retinopathy of prematurity (ROP) and blindness. Inspired oxygen concentration (FiO2) > 0.6 for more than 24 hours is toxic to the lungs and can lead to bronchopulmonary dysplasia (chronic lung disease).

2. Surfactant (PS) replacement therapy There are three types of surfactants (PS): natural, synthetic and mixed preparations. Natural preparations extracted from amniotic fluid, bovine lung, porcine lung or sheep lung washings are more effective than synthetic ones. Mixed preparations are made by adding a small amount of synthetic dipalmitoyl phosphatidylcholine and phospholipid glycerol to natural preparations.

Generally, 100 to 200 mg/kg of surfactant (PS) preparation is suspended in 4 ml of normal saline and dripped into four different body positions (supine, right and left side, and then supine) through the endotracheal tube as soon as possible. Pressurized breathing is performed with a mask bag resuscitator for 1 to 2 minutes to ensure that PS is evenly distributed in the lungs on both sides. Symptoms can be seen to improve 1 to 2 hours after medication, and the same dose is repeated every 12 hours. The cure rate can be increased to more than 90% by multiple treatments (2 to 3 times) within 2 days after birth. Giving PS before normal breathing after birth can play a preventive role.

The above article gives you a detailed introduction to the treatment methods of neonatal hyaline membrane disease. I believe you already have a preliminary understanding. So in normal times, if your child also has such a situation, you should go to the hospital for treatment in time.