Elevated neutrophil count in newborns

If the neutrophil count of a newborn is high, this may be related to inflammation. For newborns, it may be related to purulent meningitis, sepsis or infection. At this time, it is necessary to understand the specific reasons and carry out good treatment according to the cause. Of course, antibiotics must be used first to fight infection. Strengthening care in normal times can gradually alleviate the symptoms and avoid causing greater harm to the child's health.

reason

This disease has been found all over the world. Listeria monocytogenes can be isolated from soil, water, vegetable surfaces, and human and animal feces. Humans are infected through direct contact with infected animals, and the disease is spread sporadically. Those infected by this transmission method are mostly butchers, slaughterhouse workers and veterinarians, which is related to their occupations.

The bacteria can also be spread through the digestive tract by contaminating vegetables, milk and other foods, causing outbreaks of human leukopenia. Bacteria can also cause hospital-acquired infections. Normal people have a certain natural immunity to Listeria monocytogenes infection. After infection, patients usually only show flu-like symptoms or mild meningoencephalitis.

The course of the disease is usually benign and self-limited. When a person's immune function is low, especially the phagocyte function and cellular immune function are low, bacteria enter the local small veins or lymphatic vessels through the intestinal mucosa or skin and mucosa, and then invade the blood circulation, causing sepsis. When bacteria invade tissues and organs, they can cause purulent lesions in the corresponding tissues and organs, forming scattered small abscesses. Invasion of brain tissue and meninges can cause purulent meningoencephalitis or even brain abscess. After a pregnant woman is infected, the bacteria can pass through the placenta and infect the fetus, causing miscarriage or neonatal listeriosis.

Mitigation methods

1. Treatment of the cause

Antibiotics are used to treat infectious diseases; hydroxyurea or busulfan is used to treat chronic myeloid leukemia; aspirin or corticosteroids are used to treat connective tissue diseases.

2. Plasmapheresis

The purpose of treatment is achieved by separating and removing certain disease-related pathogenic components in the patient's blood or supplementing them with normal blood components at the same time, such as white blood cell replacement for leukemia with high white blood cell count. The separation methods include: manual operation, centrifugation and purification. At present, centrifugation is commonly used at home and abroad. Centrifugation can collect and remove a large amount of pathogenic components in a short time, and has good treatment effect. The purification method is very effective in treating hepatitis, infectious diseases, tumors, autoimmune diseases, etc. However, this method is complicated to operate and expensive.