What causes low creatinine in children?

The product creatinine will appear in the metabolic process of muscles in the human body. In addition, people now often eat some meat foods, which will also produce creatinine after metabolism in the body. Under normal circumstances, creatinine will be filtered through the human glomerulus and excreted from the body. If there is a problem with kidney function, the creatinine content will be abnormal. If a child's creatinine is low, the following factors should usually be considered.

What causes low creatinine in children?

Creatinine is one of the important standards for testing kidney function in life. If any abnormality is found, you need to go to a specialist hospital for diagnosis and treatment as soon as possible to avoid the invasion of serious diseases. What then? This question is answered below, let’s find out together.

In renal function tests, when urea nitrogen and creatinine results are lower than normal values, it generally has no clinical significance. There are many reasons for low creatinine, which may be related to anemia, muscular dystrophy, muscle atrophy, leukemia, diabetes insipidus and other diseases. If the creatinine measurement value is slightly lower than the normal creatinine value, you can go to the kidney hospital for another check. If the urea nitrogen and creatinine values ​​are elevated and the urea nitrogen/urine creatinine ratio is low, the reason for the low creatinine is the possibility of renal parenchymal damage.

What are the reasons for low creatinine in children? The normal value of the ratio of urea nitrogen/urine creatinine is 20.00-100.00. Its main significance is to distinguish whether the cause is renal or prerenal (extra-renal) when the urea nitrogen or creatinine values ​​are found to be elevated. If the BUN/creatinine ratio is less than 20, the chance of kidney disease is high, and if the BUN/creatinine ratio is greater than 20, the chance of prerenal causes is high.

Does the above explanation help us to have a deeper understanding of the disease? At the same time, it should be noted that there are various reasons for low creatinine, which need to be taken seriously, the cause should be identified as soon as possible, and symptomatic treatment should be given early.

The reason for low creatinine is that after the kidneys are invaded by various causes, the damaged kidney intrinsic cells first undergo phenotypic transformation, forming pathological changes, stimulating the fibroblasts in the kidney to transform into myofibroblasts, and at the same time invade and stimulate the inherent normal renal tissue, causing the same lesions, thus forming an expansion and stimulation-type spread process from point to surface, from local to overall in the kidney.

Suggestions: Low creatinine is common in acute or chronic renal insufficiency, severe congestive heart failure, hyperthyroidism, anemia, muscular dystrophy, leukemia, vegetarians, and those taking androgens or thiazide drugs.