What should I do if my child has precocious puberty?

Many parents are very concerned about children's development problems. They all hope that their children can grow up healthy and not be troubled by any diseases. Even if their children have a minor cold, they will buy a lot of nutritious food to nourish their bodies. In fact, this approach of parents is incorrect. It is best to give their children normal eating habits and not to deliberately supplement them with some nutrition. This will make them unable to digest and lead to precocious puberty.

GnRH-A is ineffective for Albright syndrome and familial male precocious puberty. A combination of spironolactone and testosterone can be tried.

Ketoconazole: Large doses can inhibit the activity of steroid 17-20 lyase and testosterone synthesis, and can be used for male idiopathic precocious puberty. Usage: 4-8 mg/(kg·d), divided into 2-3 doses. This drug may be toxic to the liver. Liver function should be monitored carefully and the drug should be discontinued if necessary. Liver function can usually be reversed after discontinuation of the drug.

Danazole: It is a synthetic steroidal heterocyclic compound and a derivative of 17a-ethynyltestosterone. It has the effects of inhibiting ovarian estrogen synthesis, ovarian follicle development, anti-gonadotropin and mild androgenic effects, so it can be used to treat precocious puberty.

Surgical treatment: Surgery should be performed as soon as possible after the tumor is diagnosed. Hypothalamic-pituitary-pineal tumors can be treated with gamma knife. After irradiation, the tumor will shrink significantly and precocious puberty can be significantly alleviated.

Idiopathic precocious puberty: The cause is neuroendocrine dysfunction, which leads to premature initiation of GnRH pulse secretion. It means that a comprehensive examination of children with this syndrome fails to reveal any organic lesions that cause early puberty. The disease includes sporadic (the majority) and familial. Familial precocious puberty often affects boys and is passed down from fathers to sons. It may be a recessive chromosomal genetic disease limited to males. Studies have found that familial male precocious puberty is caused by activating mutations in the LH-R gene. After the LH-R mutation that develops in the embryonic period begins to express, the child will be born with a large penis and show obvious precocious puberty at the age of 3 to 4 years old. The pathogenesis is that the mutated LH-R activates G protein prematurely, and the stimulated Leydig cells synthesize and secrete large amounts of androgens. Women with LH-R gene mutations do not express it and can pass the disease-causing gene to their male offspring.

In fact, there are many types of precocious puberty, so when your child suffers from precocious puberty, the first thing to do is to confirm which type of precocious puberty your child has. Some children suffer from precocious puberty due to malignant tumors. If this is the cause, surgery must be performed to remove it, usually using laser removal. This method will cause much less harm to the child's body and can effectively eliminate the related symptoms of precocious puberty.