How to treat precocious puberty in children?

Precocious puberty is a problem faced by many children today, and the occurrence of precocious puberty makes many parents feel incredible. There are many factors that lead to precocious puberty in children, and with the development of the times, the age at which children experience precocious puberty is getting younger and younger, which makes more parents begin to worry about whether their children will experience precocious puberty too early. Parents of children who have already experienced precocious puberty would like to know more about the treatments for their children's precocious puberty.

1. Etiological treatment: For intracranial, gonadal, and adrenal tumors, surgical resection or radiotherapy can be adopted. For patients with congenital adrenal hyperplasia and hypothyroidism, appropriate hormone replacement therapy is used.

2. The application of sex hormone antagonists and inhibitors.

1. Luteinizing hormone-releasing hormone analogue (GnRHa): GnRHa is the first choice drug for the treatment of central precocious puberty and is not used to treat pseudo-precocious puberty. The goals of treatment are to improve adult height, delay the progression and speed of maturation of secondary sexual characteristics, prevent premature menarche, and prevent the emergence of psychosocial problems. GnRHa changes the structure of natural GnRH, making it have a stronger affinity with the GnRH receptor, while also having a long half-life and being less susceptible to degradation. Currently, the treatment mostly uses sustained-release preparations of LHRH, the main preparations of which are triptorelin and leuprorelin (enaptoplastin). Non-sustained-release preparations and nasal inhalation preparations used in the 1980s are almost no longer recommended.

2. Danazol: It is a synthetic steroidal heterocyclic compound and a derivative of 17α-ethynyltestosterone. It inhibits estrogen synthesis and ovarian follicle development, can bind to progesterone receptors, accelerate the clearance of progesterone, has strong anti-gonadotropin and weak androgenic effects, and directly inhibits the secretion of GnRH and GH. The dosage is 100-200 mg orally once a night. Adverse reactions include skin allergies, weight gain, elevated transaminase, hematuria, and headache. Liver function and urine routine tests should be reviewed regularly.

3. Cyproterone acetate: It is a derivative of 17-hydroxyprogesterone. It has strong anti-androgenic effect and progesterone activity. It can inhibit the secretion of gonadotropin.

The growth and development of children is related to the surrounding environment. It is recommended that parents should pay more attention to their children's behavioral changes, communicate more with their children to understand their inner thoughts in a timely manner, get along with their children as friends, guide their children's inner thoughts in a timely manner, and try to avoid letting their children experience precocious puberty too early.