Pathology of juvenile rheumatoid arthritis

Juvenile rheumatoid arthritis is a very harmful disease. We know that juvenile rheumatoid arthritis can easily bring many-sided effects to young children. Therefore, parents and friends must pay attention to juvenile rheumatoid arthritis in daily life. If you find that your children at home have symptoms of juvenile rheumatoid arthritis, you must send the children to the hospital for consultation in time.

The pathological changes of this disease are mainly joint lesions. It is a chronic non-suppurative synovitis. In the early stage, the synovial membrane of the joint is congested and edematous. Accompanied by infiltration of lymphocytes and plasma cells. The synovial effusion increases and the synovial membrane proliferates to form villous protrusions in the joint cavity. The synovitis continues to progress and enters the late stage. Synovial villous hyperplasia involves articular cartilage. And form pannus. Cartilage can be absorbed. Subchondral bone is eroded. Subsequently, the joint surfaces adhere to each other and the joint cavity is replaced by fibrous tissue. Cause joint stiffness, deformity or subluxation.

Joint destruction rarely occurs in children with rheumatoid arthritis. Nonspecific fibrinous serositis may occur in the pleura, pericardium, and peritoneum. The histological changes of rheumatoid rash are subepithelial small vessel vasculitis. The cause of this disease is still not fully understood. The pathogenesis is generally believed to be related to immunity, infection and genetics. It seems to be a type III allergic reaction, causing damage to connective tissue. It may be due to infection with microorganisms (bacteria, mycoplasma, viruses, etc.) that continuously stimulates the body to produce immunoglobulins. Serum IgA, IgM, and IgG increased.

In the above article, we introduced a symptom that is common in young children, that is, rheumatoid arthritis. We know that rheumatoid arthritis in children is very harmful, so parents and friends should pay attention. The above article introduces the pathology of rheumatoid arthritis in children in detail.