Is high crp in newborns serious?

Generally speaking, if the crp of a newborn is relatively high, it is usually because the baby is infected with a virus. In this case, the baby usually needs to go to the hospital for infusion treatment. If the baby is treated in time, there is generally no big problem. The baby must drink more water and urinate frequently. If breastfeeding, the mother must eat a light diet and eat more vegetables and fruits.

CRP is part of the body's nonspecific immune mechanism. It binds to C-polysaccharide and can bind to choline phosphate on the cell membrane in the presence of Ca2+. It can activate the classical complement pathway, enhance the phagocytic function of leukocytes, regulate the function of lymphocytes or monocyte/macrophage system, and promote the production of macrophage tissue factor. CRP can also be detected in atherosclerotic plaques.

The main biological function of human CRP is to activate the complement and mononuclear phagocyte systems by binding to ligands (phosphocholine of apoptotic and necrotic cells, or invading bacteria, fungi, parasites, etc.), and to eliminate pathological substances or pathogens carrying ligands.

1. Identify foreign substances and activate the complement system.

2. Enhance the conditioning effect and phagocytic effect of phagocytes

3. Bind to platelet activating factor (RAF) to reduce inflammatory response.

4. Combine with chromosomes and eliminate cell DNA in necrotic tissue.

Application of serum CRP determination in common diseases

1. Postoperative stage for adults:

All types of surgery cause inflammation, with the acute phase response being roughly proportional to the degree of tissue damage. In uncomplicated cases, CRP reaches 10 mg/L in about 6 hours, rarely exceeds 150 mg/L at its peak at 48 hours, and returns to baseline within 7-10 days. Postoperative complications, such as infection, tissue necrosis, and hematoma such as thrombosis, will cause CRP to remain elevated or lead to secondary elevation after 48 hours, depending on the time of occurrence. In many cases, the elevation of CRP preceded the clinical diagnosis of complex pathology by more than 24 hours. Patients at risk for infection (more than 10% of patients who have undergone partial colectomy) should be monitored by daily measurement of CRP. For the diagnosis of deep vein thrombosis that meets clinical explanations, the literature reports that CRP determination has a sensitivity of 100% and a specificity of approximately 52%.

2. Acute pancreatitis :

Acute pancreatitis usually causes an increase in CRP within the first 24 hours; if there are no complications, this value decreases by the end of the first week. If the CRP is greater than 100 mg/L at this time, complications such as cysts or pseudocysts are likely to have formed, which can be confirmed by ultrasound and radiological examinations. If the CRP is greater than 110 mg/L on admission, it may be hemorrhagic pancreatitis (clinical sensitivity 88%, specificity 94%).

3. Genital infection, pelvic inflammatory disease:

Uncomplicated chlamydial infections such as gonococcal infections do not cause an increase in CRP, but they can spread to the pelvic tissues and cause an acute phase reaction due to acute or chronic pelvic inflammatory disease. In one study, 81% of cases with adnexitis had elevated CRP, while only 52% had leukocytosis, so CRP is a valuable data that can be considered as a check for this patient.

4. Appendicitis:

Using 10 mg/L as the cutoff value, it has been reported that the clinical sensitivity of CRP is 68.2% and the specificity is 75.1%, while the corresponding values ​​for elevated neutrophils are 87.2 and 63%.

5. Lung infection:

Pneumonia is more difficult to diagnose in the elderly, who often do not have a fever. In many cases CRP is greater than 100 mg/L, strongly suggesting bacterial infection such as pneumonia or purulent bronchitis. Typical viral pneumonia will not exceed 50 mg/L.

6. Fever in children:

In children, although fever caused by viral infection is the most common, it is still difficult to distinguish it from bacterial sepsis, such as otitis media, tracheitis, tonsillitis, and cystitis, and there is no need to use antibiotics frequently. The results showed that in children who were sick for more than 12 hours, the CRP was much higher than 40mg/L. The sensitivity for diagnosing bacterial infection is 79% and the specificity is 90%. If the ESR is much higher than 30 mm/h, the sensitivity is 97% and the specificity is 89%, which should be paid attention to.

7. Myocardial infarction:

Myocardial infarction is often associated with elevated CRP concentrations, often occurring within a few hours of the onset of pain and typically peaking within 3-4 days. 7-10 days after CK-MB returns to normal, CRP also returns to normal. Elevated CRP levels in the presence of suggestive symptoms are a sensitive indicator of this condition. In acute myocardial infarction, 49 out of 50 people experience this situation, and all of the 100 people experience significant electrocardiogram Q wave changes. If the changes remain elevated after 10 days, it indicates the presence of complications and a poor prognosis. Recent data show that high circulating levels of CRP predict the development of coronary heart disease in patients with stable or unstable angina.

8. Gouty arthritis:

In gout, mild to severe elevations of CRP are common, whereas in pseudogout, elevations are less common.

9. Osteoarthritis:

In this case, elevated CRP is primarily due to degeneration rather than inflammation.