What is the normal crp value for children?

Many people do not know the meaning of crp. In fact, crp is simply an acute phase protein produced by the body in an emergency. It is generally secreted by the human liver. Generally speaking, the normal value of crp for school-age children is 0.17-2.2 mg/L. If the child's crp value is relatively good, it means that the body is inflamed, which may be a bacterial infection. The baby needs to be treated with anti-inflammatory treatment in time.

CRP is part of the body's nonspecific immune mechanism. It binds to C-polysaccharide and can bind to choline phosphate on the cell membrane in the presence of Ca2+. It can activate the classical complement pathway, enhance the phagocytic function of leukocytes, regulate the function of lymphocytes or monocyte/macrophage system, and promote the production of macrophage tissue factor. CRP can also be detected in atherosclerotic plaques.

The main biological function of human CRP is to activate the complement and mononuclear phagocyte systems by binding to ligands (phosphocholine of apoptotic and necrotic cells, or invading bacteria, fungi, parasites, etc.), and to eliminate pathological substances or pathogens carrying ligands.

1. Identify foreign substances and activate the complement system.

2. Enhance the conditioning effect and phagocytic effect of phagocytes

3. Bind to platelet activating factor (RAF) to reduce inflammatory response.

4. Combine with chromosomes and eliminate cell DNA in necrotic tissue.

Reference value ≤10mg/L

CRP increases within hours of the onset of inflammation, reaches a peak within 48 hours, and then returns to normal levels as the lesions subside and tissue, structure, and function recover. This reaction is not affected by radiotherapy, chemotherapy, or corticosteroid therapy. Therefore, CRP testing is widely used in clinical practice, including the diagnosis and differential diagnosis of acute infectious diseases, monitoring of postoperative infection, observation of antibiotic efficacy, disease course detection and prognosis judgment, etc. Its clinical applications are as follows:

[Evaluation of disease activity and efficacy monitoring]

The degree of CRP increase reflects the size or activity of inflammatory tissue. In acute inflammation and infection, CRP has a good correlation with disease activity. This situation is not consistent with chronic inflammation, although in some important conditions such as rheumatoid arthritis, Crohn's disease, and polymyalgia rheumatica, this association is sufficient to monitor treatment.

1. A CRP value of 10-50 mg/L indicates mild inflammation, such as local bacterial infection (such as cystitis, bronchitis, abscess), surgery and accidental trauma, myocardial infarction, deep vein thrombosis, inactive connective tissue disease, many malignant tumors and most viral infections.

2. A CRP value of around 100 mg/L indicates a more serious disease, and the degree of inflammation requires intravenous injection if necessary.

3. CRP values ​​greater than 100 mg/L indicate a serious disease process and often indicate the presence of bacterial infection.