Henoch-Schonlein purpura is a relatively serious disease that can cause great harm to adults, let alone children. Children suffering from Henoch-Schonlein purpura will have a variety of symptoms as the disease progresses, the most common of which are nausea and vomiting, accompanied by severe pain. 1. Skin purpura is characterized by repeated appearance of skin purpura during the course of the disease, which is more common on the limbs and buttocks, with symmetrical distribution, more on the extensor side, appearing in batches, and less on the face and trunk; it initially appears as purple-red maculopapules that are higher than the skin surface, then turns brown and disappears, and may be accompanied by urticaria and angioedema. In severe children, purpura may merge into bullae with hemorrhagic necrosis. 2. Gastrointestinal symptoms More than half of the children experience recurrent paroxysmal abdominal pain located around the umbilicus or lower abdomen. The pain is severe and may be accompanied by vomiting, but hematemesis is rare. Some children have black or bloody stools, diarrhea or constipation, and occasionally have complications such as intussusception, intestinal obstruction or intestinal perforation. 3. Joint symptoms include swelling and pain in large joints such as the knees, ankles, elbows, and wrists, limited mobility, and single or multiple joints. There is fluid accumulation in the joint cavity, which can disappear within a few months without leaving any sequelae. 4. Renal symptoms The renal lesions caused by this disease are the most common secondary glomerular diseases in children. Kidney symptoms vary in severity. Most children have hematuria, proteinuria, and casts, accompanied by increased blood pressure and edema, which is called purpuric nephritis. A few present with nephrotic syndrome. Most kidney symptoms appear within 1 month of onset, but may also occur in the later stages of the disease. A few have nephritis as the first symptom. Although some children have hematuria and proteinuria that persist for months or even years, most recover completely. A few develop chronic nephritis and die of chronic renal failure. 5. Other symptoms include intracranial hemorrhage, leading to convulsions, paralysis, coma, aphasia, and bleeding symptoms such as nose bleeding, gingival bleeding, hemoptysis, and testicular bleeding. Occasionally, the circulatory system may be affected, resulting in myocarditis and pericarditis, or the respiratory system may be affected, resulting in laryngeal edema, asthma, and pulmonary hemorrhage. |
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