What are the symptoms of thalassemia in babies?

The disease of thalassemia is somewhat hereditary, so if some babies have thalassemia, this disease will cause great trouble to the family. The status of children in a family is very important. The disease of thalassemia has been very troubling to people in recent years. In response to this situation, today I will tell you what are the symptoms of thalassemia in babies?

Thalassemia is also known as thalassemia. Is a group of inherited hemolytic anemias. Their common feature is that due to defects in the globin gene, the synthesis of one or more globin peptide chains in hemoglobin is reduced or cannot be synthesized. This leads to changes in the composition of hemoglobin. The clinical symptoms of this group of diseases vary in severity, and most of them manifest as chronic progressive hemolytic anemia.

1. Symptoms :

This disease usually occurs in infancy, with symptoms of anemia, weakness, and abdominal lumps. Developmental retardation, etc., severe cases are often growth retardation and often lead to death before adulthood. Patients with mild and intermediate cases can generally live to adulthood and participate in labor. If they pay attention to energy conservation and diet and daily life, they can reduce complications and improve symptoms.

2. Physical signs:

In beta-thalassemia major, skeletal x-rays show features of chronic bone marrow overactivity. The cortical layer of the skull and long bones becomes thinner and the medullary cavity becomes wider. The skull lamellar spaces are obvious, and the lamellar trabeculae have sun-ray-like radial lines. Areas of osteoporosis may develop in the long bones. The pyramids and skull may have a granular or ground-glass appearance. The phalanges lose their normal shape and become rectangular or even convex on both sides.

3. Diagnostic criteria:

Quantitative determination of hemoglobin is a routine clinical diagnostic method. An increase in HbA2 is diagnostic of beta-thalassemia minor. In severe β-thalassemia, HbF usually increases, sometimes to 90%; the increase in HbA2 is usually also above 3%. In alpha-thalassemia syndrome, HbA2 and F percentages are usually normal, and the diagnosis is often based on exclusion of other causes of microcytic anemia. HbH disease is diagnosed when fast-moving HbH or Bart fragments are shown on hemoglobin electrophoresis. Recombinant DNA genome mapping technology, particularly using the polymerase chain reaction method, is very important in prenatal diagnosis and genetic counseling.

The above describes the symptoms of thalassemia in babies, so parents with children at home can take their children to a regular hospital for treatment based on the symptoms mentioned above. Today's medicine is so advanced, so we must have the confidence to believe that it can be cured. If a life is born with a disease, it will affect him for the rest of his life. I wish the newborn can recover as soon as possible and grow up happily.