Causes of cleft lip in babies

Cleft lip is a congenital deformity. The most famous example is that Faye Wong and Li Yapeng's child has cleft lip, which requires correction through surgery. There are many reasons for cleft lip in babies. This disease is hereditary, and it is very difficult to prevent even if the cause is known. But don't worry too much. The current treatment effect is still quite good. The key is to actively carry out treatment. Let’s take a look at the main causes of cleft lip.

Genetic factors also play a certain role in the occurrence of cleft lip. The probability of family members suffering from congenital diseases such as cleft lip passing them on to the fetus is about 4%. The probability of infants and young children having cleft lip may be related to the occurrence of cleft lip in direct or collateral relatives. If a relative has a similar deformity, the possibility of the newborn having cleft lip will also increase. Therefore, it is believed that cleft lip deformity has a certain relationship with genetics.

Genetic research suggests that cleft lip is a polygenic hereditary disease. Epidemiological surveys have shown that the incidence of cleft lip in offspring of persons whose direct relatives have cleft lip deformity is higher than that in relatives who do not have cleft lip deformity. Genetic factors are often difficult to avoid, but the chance of your baby developing cleft lip can be reduced by minimizing the interference of environmental factors.

The factors that cause cleft lip are not only related to genetic factors, but also to environmental factors. The environmental factors mentioned here mainly refer to the environment in which the embryo grows and develops. The entire physiological state of the mother constitutes the environmental conditions for embryonic development, including nutritional factors, infection and injury, endocrine influences, drug factors, physical damage, and tobacco and alcohol factors. Therefore, during the first three months of pregnancy, when the mother's physiological state is invaded or disturbed, it may affect the growth and development of the embryo's maxillofacial region.

(1) Nutritional factors.

If a pregnant woman lacks nutrients such as vitamin A, B2 and folic acid during pregnancy, the baby may have a higher chance of developing cleft lip. According to animal experiments, when mice lack food ingredients such as vitamin A, B2 and folic acid, researchers found that newborn mice may develop deformities such as cleft lip. Therefore, nutritional deficiencies in early pregnancy may induce cleft lip in babies.

Infection and injury are also causes of cleft lip. If the mother accidentally suffers some injuries and injuries in the early stages of pregnancy, especially injuries to the uterus and its surrounding parts, such as improper incomplete abortion or unscientific medical abortion, it will affect the normal development of the fetus, thereby inducing deformities and congenital deformities such as cleft lip. In addition, when the mother is infected with a virus, such as rubella, it can also affect the development of the embryo and induce cleft lip.

(3) Endocrine effects

It is mainly related to the hormone components in the mother's body. If women use hormone treatment for illness in early pregnancy, their babies may have certain congenital malformations. In addition, in the investigation of the family history of children with cleft lip, studies have also found that if the mother has experienced some kind of mental trauma in the early stages of pregnancy, she will normally have a stress response, which will increase the secretion of adrenaline in the body, affect normal endocrine, and may induce congenital malformations.