What should I do if adenovirus infection is difficult to cure in children?

Adenovirus is a relatively acute infectious disease in daily life. It is easy to infect the human respiratory tract or urinary system. It usually occurs in children. Because children have poor resistance during their growth, they are prone to physical infections and cause great harm to their health. Children infected with adenovirus need to seek medical attention in time to suppress the infection.

What should I do if adenovirus infection is difficult to cure in children?

1. There is currently no effective treatment.

2. Clinically, symptomatic treatment is mainly adopted to prevent and treat secondary infection.

3. Antiviral treatment.

4. Interferon α can be used to treat severe cases.

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1. Rapid diagnosis method

The exfoliated cell smear taken from the pharynx was stained with polyvalent adenovirus fluorescent immune serum. Bright fluorescence was seen in the nuclei of the exfoliated cells under a fluorescence microscope, indicating that the virus was positive.

2. Virus Isolation

When the monolayer of human epithelial cells are inoculated with pharyngeal secretions, sputum, conjunctival scrapings and fresh urine of different clinical types, typical cytopathic changes can be detected after 2 to 7 days. The grouping was determined by hemagglutination test and the typing was determined by neutralization test.

3. Serological examination

If you want to confirm the disease, you can take two samples of serum from the acute phase and the recovery phase, and test the complement binding antibodies, neutralizing antibodies and hemagglutination inhibition antibodies. If a 4-fold increase is found. Different types of antibodies have different titers after infection:

(1) The titer of complement-fixing antibodies decreases or disappears one year after infection;

(2) Hemagglutination inhibition antibodies are specific antibodies, and the antibody titer increases one week after infection;

(3) Neutralizing antibodies persist for at least 10 years without decreasing in titer. The diagnosis of hemorrhagic cystitis can be confirmed if the neutralizing antibody titer of adenovirus type 11 or 21 in a single serum sample of a patient exceeds 1:32.

4. Molecular Diagnosis

Respiratory specimens are taken and the diagnosis is made by amplifying adenovirus-specific gene fragments using the PCR method.

Differential Diagnosis

Differentiate from herpes virus, poxvirus, influenza, parainfluenza, and rhinovirus infections.

1. Influenza

(1) The incubation period ranges from a few hours to 4 days, usually 1 to 2 days;

(2) High fever, with body temperature reaching 39°C to 40°C, accompanied by chills, usually lasting 2 to 3 days;

(3) Severe systemic poisoning symptoms, such as fatigue, headache, dizziness, and body aches; long duration, fatigue and other symptoms may last for 1 to 2 weeks after the body temperature returns to normal;

(4) Symptoms of respiratory catarrh are mild, often with sore throat, and a few with nasal congestion and runny nose.

2. Poxvirus

A virus that often causes local or systemic purulent skin lesions if it infects humans and animals.