Disadvantages of the second generation of test tube babies

For infertile men, IVF is undoubtedly the best solution. Now many celebrities have decided to have their own babies through IVF. For couples, having a child will make the family more complete. Children are the hope of the family. Many people choose IVF. Next, we will analyze in detail some of the defects of the second-generation IVF for you.

With the gradual increase in the number of infertile couples, the treatment of male infertility through assisted reproductive technology ICSI has been widely used throughout the world, making it possible for infertile men to become biological fathers. However, in the majority of infertile males, the etiology of infertility is unknown (i.e., primary), and using this technology to treat male infertility has the potential to pass on genetic and epigenetic genetic diseases to the next generation.

Intracytoplasmic sperm injection (ICSI) technology can be used for male oligospermia, asthenospermia, sperm deformity, azoospermia and failure of conventional in vitro fertilization cycles. It overcomes the problem of insufficient sperm count and can even directly obtain sperm from the epididymis and testicles to treat infertility. This technique directly injects a single sperm into an egg, which violates the biological laws of natural fertilization and carries great genetic risks. This article reviews the genetic and epigenetic defects of ICSI sperm and their related diseases, which can further understand the molecular mechanism of ICSI sperm genetic and epigenetic defects leading to increased genetic risks in offspring. The article explains the necessity of strict quality control of ICSI sperm through epigenetic factors such as DNA methylation and histone acetylation to effectively reduce the risks of ICSI genetic and epigenetic defects.

The above content is a brief introduction to the defects of the second-generation IVF. For parents who want to solve fertility problems through IVF, they must consider these factors comprehensively before making a decision, because IVF also has certain risks, and current technology cannot achieve 100% success.