What are the side effects of precocious puberty injections?

Precocious puberty usually refers to the early development of sexual characteristics in children before the age of eight or nine. Children with precocious puberty often have some physical or psychological complications. For parents, children's precocious puberty is indeed a worrying issue. For this reason, many parents seek various methods, such as taking medicine and injections, to suppress their children's precocious puberty. So, when a child has precocious puberty, are there any side effects of injections?

Males: In the early stages of treatment, as the blood testosterone level transiently increases, some patients may experience aggravation of urinary tract symptoms, bone pain caused by bone metastasis, and spinal cord compression caused by vertebral metastasis. These symptoms will disappear after 1-2 weeks.

The most commonly reported adverse reactions during treatment (hot flashes, decreased libido, and impotence) were related to decreased plasma testosterone, which is a result of the drug's pharmacological effects and is similar to adverse reactions observed with other GnRH analogs.

Women: In the early stages of treatment, due to a transient increase in plasma estradiol levels, symptoms of endometriosis (pelvic pain, dysmenorrhea) may worsen, but disappear after 1-2 weeks. Uterine bleeding may occur within one month after the first injection.

When this drug is used to treat female infertility, the combined use of gonadotropins can cause ovarian stimulation, which may lead to ovarian enlargement, pelvic pain and/or abdominal pain.

During treatment, the most commonly reported adverse reactions such as hot flashes, vaginal dryness, decreased libido, and dyspareunia are related to pituitary-ovarian blockade. Headache, arthralgia and myalgia have been reported rarely.

Male and female: Allergic reactions such as urticaria, rash, and itching have been reported. Quincke's edema may rarely occur. Some patients experience nausea, vomiting, weight gain, high blood pressure, mood disturbances, fever, abnormal vision, and pain at the injection site.

Long-term use of GnRH analogs can cause bone loss and the risk of osteoporosis.

Children: Initial stimulation of the ovaries may cause a small amount of vaginal bleeding in girls. As in adults, allergic reactions such as urticaria, rash, itching, and rarely Quincke's edema have been reported in children. Some children experience nausea, vomiting, weight gain, high blood pressure, mood disturbances, fever, abnormal vision, and pain at the injection site.

The above adverse reactions may occur even when the treatment achieves satisfactory results. If the patient experiences the above adverse reactions or adverse reactions not listed in this manual, please notify the doctor immediately.