The health of children is very important, and it is particularly important for parents, because children's bodies are very fragile, and it is easy for them to suffer serious adverse consequences due to some simple illnesses. For example, rash on children is one of the common factors. This phenomenon is a typical disease problem and is very detrimental to the growth and development of children. Let's take a look at what to do if children have rash on them? Urticaria is more likely. It is an allergic reaction. (1) Antihistamine drugs ①H receptor antagonists have strong anti-histamine and anti-other inflammatory mediator effects and are effective in treating various types of urticaria. Doxepin is a better choice of drug for patients with urticaria who are not responsive to traditional antihistamines. (2) Drugs that inhibit mast cell degranulation and reduce histamine release ① Meta-hydroxyisobutyrine sulfate is a β2 adrenergic receptor stimulator that can increase the concentration of cAMP in the body, thereby inhibiting mast cell degranulation. ② Ketotifen inhibits mast cell degranulation and prevents the release of inflammatory mediators (such as histamine, slow-reacting substances, etc.) by increasing the concentration of cAMP in the body. Its suppressed. It is stronger and faster than sodium cromoglycate and can be taken orally. ③Sodium cromoglycate can block the binding of antigen and antibody and inhibit the release of inflammatory mediators. If used in combination with glucocorticoids, the dosage of the latter can be reduced and the therapeutic effect can be enhanced. ④ Tranilast reduces the release of histamine by stabilizing the mast cell membrane. (3) Glucocorticoids It is a second-line drug for the treatment of urticaria. It is generally used when severe acute urticaria, urticarial vasculitis, pressure urticaria are ineffective with antihistamines, or when chronic urticaria is severely stimulated. It is given by intravenous drip or orally, and long-term use should be avoided. Commonly used drugs are as follows: ① prednisone; ② triamcinolone; ③ dexamethasone; ④ diprosone. In emergency situations, hydrocortisone, dexamethasone, or methylprednisolone is given intravenously. (4) Immunosuppressants When patients with chronic urticaria have an autoimmune basis, the disease recurs, and the above treatments cannot achieve satisfactory results, immunosuppressants can be used. Cyclosporine has a good therapeutic effect. Azathioprine, cyclophosphamide, methotrexate and immunoglobulin can all be tried. Tripterygium wilfordii also has a certain therapeutic effect. Due to the high incidence of side effects of immunosuppressants, they are generally not recommended for the treatment of urticaria. |
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