Causes of aplastic anemia in children

Children's physical health is what the family is most concerned about. If a child has any abnormal physical condition, parents will be very worried and don't know what to do. We suggest that parents and friends need to learn more about how to care for children. Aplastic anemia is a disease that is common in children. So what factors lead to the occurrence of this symptom? Below we introduce the causes of aplastic anemia in children.

1. Medication

It is the most common cause of disease.

2. Chemical poisons

The relationship between benzene and its derivatives and aplastic anemia has been confirmed by many experimental studies. Benzene is easily fixed in fat-rich tissues when it enters the human body. In chronic benzene poisoning, benzene is mainly fixed in the bone marrow. The bone marrow toxicity of benzene is caused by its metabolites, which can act on hematopoietic progenitor cells, inhibit the synthesis of their DNA and RNA, and damage chromosomes.

3. Ionizing radiation

X-rays, gamma rays or neutrons can pass through or enter cells and directly damage hematopoietic stem cells and the bone marrow microenvironment. Long-term radiation exposure exceeding the permitted amount (such as radiation source accidents) can cause aplastic anemia.

4. Viral infection

The relationship between viral hepatitis and aplastic anemia has been confirmed, which is called viral hepatitis-associated aplastic anemia, and is one of the most serious complications of viral hepatitis. The type of hepatitis that causes aplastic anemia has not yet been confirmed, it may be hepatitis C, and the rest are caused by hepatitis B.

5. Immune factors

Aplastic anemia can be secondary to thymoma, systemic lupus erythematosus and rheumatoid arthritis, etc., and antibodies that inhibit hematopoietic stem cells can be found in the patient's serum. Some cases of aplastic anemia of unknown cause may also involve immune factors.

6. Genetic factors

Anemia is an autosomal recessive genetic disease that runs in families.

7. Paroxysmal nocturnal hemoglobinuria (PNH)

PNH and aplastic anemia are closely related, as both are diseases of hematopoietic stem cells. A clear transition from aplastic anemia to PNH, but the symptoms of aplastic anemia are no longer obvious; or a clear transition from PNH to aplastic anemia, but the symptoms of PNH are no longer obvious; or PNH combined with aplastic anemia and aplastic anemia combined with PNH red blood cells, can all be called aplastic anemia-PNH syndrome.

8. Other factors

There are rare case reports of aplastic anemia occurring during pregnancy, resolving after delivery or induced abortion, and then recurring during a second pregnancy, but most people believe that this may be a coincidence. In addition, aplastic anemia can also be secondary to chronic renal failure, severe hypothyroidism or anterior pituitary dysfunction, etc.

In the above article, we introduced one of the things that parents are most concerned about, that is, the physical health of their children. We recommend that parents learn some knowledge of pediatric nursing. The above article gives us a detailed introduction to the causes of aplastic anemia in children.