child

We all know that children's bodies are generally weak in resistance. It is possible that when children are young, their organs are not fully developed. At this time, the fragile organs will be infected by external viruses. The liver of children is also used for detoxification. Sometimes when checking the body of children, it is found that the alanine aminotransferase is a little high. What is going on?

Generally speaking, elevated transaminase levels may be seen in liver function tests after strenuous activity, excessive fatigue, or cold, and when taking certain medications. Elevated transaminase levels may also occur when you have liver disease. In your current situation, all tests show normal results, so don't worry too much. You must pay attention to protecting your liver, arrange your work and rest schedule properly, eat a balanced diet, and avoid eating raw, cold, spicy, and other irritating foods. It is recommended that you have your liver function tested again.

Alanine aminotransferase increased. Aspartate aminotransferase is mainly present in the mitochondria of liver cells. Only when the liver is severely necrotic or damaged can it cause a significant increase in aspartate aminotransferase. The normal values of both transaminases are below 40 international units. If they exceed 40 international units, it can be confirmed as abnormal liver function. According to the hepatitis diagnostic standards, the severity of chronic hepatitis B patients can be divided into mild, moderate and severe. If the alanine aminotransferase is 40-120 units/liter, it is called mild hepatitis B; if the alanine aminotransferase is 120-400 units/liter, it is called moderate hepatitis B; if the alanine aminotransferase is greater than 400 units/liter, it is called severe hepatitis B. The ratio of alanine aminotransferase to aspartate aminotransferase is of great significance in determining the extent of disease progression. Generally speaking, patients with a short course of disease, mild hepatocellular damage and a better prognosis usually show a significant increase in alanine aminotransferase, and an alanine aminotransferase/aspartate aminotransferase ratio greater than 1.5; patients with a long course of disease, a high degree of chronicity, severe hepatocellular damage and a poor prognosis usually show a significant increase in aspartate aminotransferase, and an alanine aminotransferase/aspartate aminotransferase ratio less than 1.0. In general, the ALT/AST ratio in patients with early cirrhosis and cirrhosis is below 1.0. The transaminase levels of patients with chronic hepatitis are always high, reflecting that liver cell inflammation has never stopped and liver cell swelling and necrosis persist.

Common causes of elevated transaminases include:

① Diseases of the liver itself, especially various types of viral hepatitis, cirrhosis, liver abscess, liver tuberculosis, liver cancer, fatty liver, etc., can all cause varying degrees of elevated transaminase levels.

②In addition to the liver, other organs in the body** such as the heart, kidneys, lungs, brain, testicles, and muscles also contain this enzyme. Therefore, elevated blood transaminase levels may be seen in cases of myocarditis, pyelonephritis, lobar pneumonia, tuberculosis, Japanese encephalitis, polymyositis, acute sepsis, typhoid fever, meningitis, malaria, cholecystitis, leptospirosis, influenza, measles, schistosomiasis, crush syndrome, etc.

③Because transaminase is excreted from the bile duct, if there is a disease of the bile duct, gallbladder or pancreas, or bile duct obstruction, the transaminase level may also increase.

④ Drug-induced or toxic liver damage, as well as drug allergy, can cause elevated transaminases, often accompanied by cholestatic jaundice and hepatocellular damage.

⑤Normal pregnancy, preeclampsia, acute fatty liver of pregnancy, etc. are also common causes of elevated transaminase. In addition, strenuous exercise may also cause an increase in transaminase. Chronic elevation of transaminase is a special temporary diagnosis in clinical practice, and is also the only clinical manifestation of many patients with non-viral hepatitis and liver disease. The pathogen of liver disease can be determined in most cases through medical history, physical examination and a series of tests; however, there are still some abnormal liver function that cannot be explained by routine examinations, which requires further liver biopsy to thoroughly clarify the cause. Only by figuring out which of the above situations causes the increase in transaminase can we trace the root cause and prescribe the right medicine. It is recommended to go to a specialized children's hospital to check the cause

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